- Level Foundation
- المدة 13 ساعات hours
- الطبع بواسطة Ludwig-Maximilians-Universität München (LMU)
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Offered by
عن
This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.الوحدات
Lecture 1: Introduction to chronobiology
2
Assignment
- Lecture 1, Introduction, first half.
- Lecture 1, Introduction, second half.
9
Videos
- 1.0 Introduction to the First Half of Lecture 1
- 1.1 The Family of Biological Rhythms
- 1.2 The Circa-Rhythms
- 1.3 Spatial and Temporal Niches
- 1.4 The Case of Gonyaulax polyedra
- 1.5 Introduction to the Second Half of Lecture 1
- 1.6 Circadian Rhythms in Mammals
- 1.7 Circadian Clocks in Flies, Plants and Fungi
- 1.8 Wrap up for Lecture 1
1
Readings
- Literature suggestion
Lecture 2: Circadian formalisms and entrainment
1
Assignment
- Formalisms
5
Videos
- 2.0. Introduction to Lecture 2
- 2.1 Pittendrigh´s generalisations 1-9
- 2.2 Pittendrigh´s generalisations 10 and 11
- 2.3 Pittendrigh´s generalisations 12-16 and entrainment
- 2.4 Wrap-up for Lecture 2
3
Readings
- Literature suggestion
- Translation of de Mairan's botanical observation
- Obituary Jürgen Aschoff
Lecture 3: Molecular mechanisms
1
Assignment
- Lecture 3 Molecular mechanisms
8
Videos
- 3.0 Introduction to Lecture 3
- 3.1 The first clock gene
- 3.2 The negative feedback hypothesis
- 3.3 More clock genes -many more!
- 3.4 Post transcriptional mechanisms and the clock
- 3.5 Indications of a non-transcriptional clock
- 3.6 Zeitgebers and the molecular clockwork
- 3.7 Wrap-up to Lecture 3
1
Readings
- Literature suggestion
Lecture 4: What does the circadian clock regulate: the concept of "clock control"
1
Assignment
- Lecture 4: Clock control
8
Videos
- 4.0 Introduction to Lecture 4
- 4.1 Clock control: which processes in humans and how to measure them?
- 4.2 Schwänzeltanz
- 4.3 The SCN regulates the timing of physiology and behaviour
- 4.4 Clock controlled genes (ccg´s)
- 4.5 Clock regulation of behaviour: genetic mechanisms
- 4.6 Clock regulation of other major regulatory systems
- 4.7 Wrap-Up to Lecture 4
1
Readings
- Literature suggestion
Lecture 5: Human circadian clocks in real life
1
Assignment
- Human
6
Videos
- 5.0 Introduction to Lecture 5
- 5.1 Chronotypes
- 5.2 What makes up Chronotypes?
- 5.3 Linking chronotype and light entrainment
- 5.4 How modern life styles affect sleep
- 5.5 Wrap-up to Lecture 5
1
Readings
- The link to the MCTQ
Lecture 6: Pathologies and the clock
3
Assignment
- Final Exam "Circaclock"
- Pathology
- Lecture 6. Clock and pathologies
1
Peer Review
- Peer-Reviewed Assignment
11
Videos
- 6.0 Introduction to the First Half of Lecture 6
- 6.1 What is normal and what not and why?
- 6.2 The consequences of living against the clock
- 6.3 Circadian changes and Pathologies - comorbidities or causal factors
- 6.4 Introduction to the Second Half of Lecture 6
- 6.5 Clock genes that can really mess up the timing of sleep
- 6.6 The clock gene mutant mice are sick
- 6.7 Chronopharmacology and chronochemotherapy
- 6.8 The circadian clock is a fitness characteristic
- 6.9 Wrap-up to Lecture 6
- 6.10 Farewell from your CircaClock Team
Auto Summary
Discover the fascinating world of circadian clocks and how they structure life in this foundational science and engineering course. Designed for early undergraduate students, it offers valuable insights for those pursuing careers in life sciences. With a duration of 780 minutes, learners can subscribe through Starter or Professional options. A background in biology is beneficial but not essential. Join Coursera and explore the rhythms that govern our biological clocks.
Martha Merrow

Till Roenneberg