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- المدة 27 ساعات hours
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Course 3 of a three course specialization called Fundamentals of Immunology. Each course in the specialization presents material that builds on the previous course's material. This is the third leg of the journey through the defenses your body uses to keep you healthy. In the first course we learned about innate immunity and B cell function. In the second course we studied T cell function and coordination of the immune response. Fundamentals of Immunology: Death by Friendly Fire introduces students to the basic functions of the adaptive and innate immune systems. The early lectures survey cells, tissues and organs using metaphors, cartoons and models to improve understanding and retention. After describing the form, function, origin and varieties of antibodies, subsequent lectures provide details on the mechanism of the generation of variation. The course provides animations of gene rearrangement and class switching and descriptions of affinity maturation correlated with detailed physical models of antibody structure. The final lecture reviews these concepts in anatomical context. Testing employs multiple choice questions testing facts, concepts, and application of principles. Questions may refer to diagrams, drawing and photographs used in lecture and reproduced in the outline. What You'll Learn: A survey of immune cells and how they attack pathogens, with emphasis on the mechanism of inducing apoptosis and details of Antibody Directed Cell-mediated Cytotoxicity. The inflammatory response and mechanisms of generating tolerance, presented in sequence to emphasize the decision making involved in controlling attacks. A survey of autoimmune disease, their characteristics, cause and treatment. Survey of hypersensitivity reactions, including allergy, anaphylaxis, anemias, granulomas, and a variety of skin responses. This is accompanied by identification, prevention and treatment. The final discussion of preventing transplant rejection is preceded by a detailed unit on antibody technology and the methods of testing for incompatibility.الوحدات
Welcome
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1
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3
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- Welcome
3
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- Course Information and Syllabus
- Course Outline
- Pre-Course Survey
Lesson 1 - Cellular Immunity
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- Cellular Immunity
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- Lesson 1 Questions
Lesson 2 - Quasi-Innate Adaptive Cells: Border Patrol
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1
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Assignment
- Lesson 2 Questions
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- Quasi-Innate Adaptive Cells: Border Patrol
Lesson 3 - Out of the Bone Marrow: Spectrum and Variety
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- Out of the Bone Marrow: Spectrum and Variety
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- Lesson 3 Questions
Lesson 4 - Attack by Tc Cells
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- Attack by Tc Cells
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- Lesson 4 Questions
Lesson 5 - Attack by NK Cells
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- Attack by NK Cells
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- Lesson 5 Questions
Lesson 6 - Coordinated Killing: ADCC
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- Coordinated Killing: ADCC
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- Lesson 6 Questions
Quiz 1
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- Review Quiz 1
- Quiz 1
Lesson 1 - Metaphor
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- Metaphor
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- Lesson 1 Questions
Lesson 2 - Signals
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- Signals
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- Lesson 2 Questions
Lesson 3 - Cell Adhesion
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- Cell Adhesion
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- Lesson 3 Questions
Lesson 4 - Extravasation
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- Extravasation
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- Lesson 4 Questions
Lesson 5 - Inflammasomes
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- Inflammasomes
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- Lesson 5 Questions
Lesson 6 - Inflamatory Mediators
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- Inflamatory Mediators
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- Lesson 6 Questions
Lesson 7 - Clinical Considerations
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- Clinical Considerations
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- Lesson 7 Questions
Lesson 8 - Clinical Therapies
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- Clinical Therapies
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- Lesson 8 Questions
Quiz 2
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- Review Quiz 2
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Lesson 1 - Danger Assessment
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- Danger Assessment
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- Lesson 1 Questions
Lesson 2 - Central Tolerance
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- Central Tolerance
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- Lesson 2 Questions
Lesson 3 - Peripheral Tolerance
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- Peripheral Tolerance
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- Lesson 3 Questions
Lesson 4 - Experiments and Mechanisms
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- Experiments and Mechanisms
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- Lesson 4 Questions
Lesson 5 - T regulatory cells
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- T regulatory cells
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Lesson 6 - Thought Questions
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- Thought Questions
Lesson 7 - Mutation
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- Mutation
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Lesson 8 - Implications and Analogy
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- Implications and Analogy
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Quiz 3
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Lesson 1 - Systemic
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- Systemic
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- Lesson 1 Questions
Lesson 2 - Endocrine
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- Endocrine
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- Lesson 2 Questions
Lesson 3 - Neuromuscular
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- Neuromuscular
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- Lesson 3 Questions
Lesson 4 - Epithelia
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- Epithelia
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- Lesson 4 Questions
Lesson 5 - Mechanisms
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- Mechanisms
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- Lesson 5 Questions
Lesson 6 - Therapy
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- Therapy
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Quiz 4
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Lesson 1 - Type I: Characteristics and Diseases
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- Type I: Characteristics and Diseases
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Lesson 2 - Type I: Mechanism of Action
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- Type I: Mechanism of Action
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- Lesson 2 Questions
Lesson 3 - Type I: Therapies and Epidemiology
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- Type I: Therapies and Epidemiology
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- Lesson 3 Questions
Lesson 4 - Type II: ADCC
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- Type II: ADCC
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Lesson 5 - Type II: Clinical Consequences
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- Type II: Clinical Consequences
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Lesson 6 - Type III: Immune Complex Mediated
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- Type III: Immune Complex Mediated
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- Lesson 6 Questions
Lesson 7 - Type IV: Cellular or Delayed
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- Type IV: Cellular or Delayed
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- Lesson 7 Questions
Lesson 8 - Wrap-up
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- Wrap-up
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- Lesson 8 Questions
Quiz 5
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Lesson 1 - Antibodies and Assays
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- Antibodies & Assays
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- Lesson 1 Questions
Lesson 2 - ELISA Assays
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- ELISA Assays
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- Lesson 2 Questions
Lesson 3 - Graft Rejection
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- Graft Rejection
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- Lesson 3 Questions
Lesson 4 - MHC and Tissue Typing
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- MHC and Tissue Typing
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- Lesson 4 Questions
Lesson 5 - Encouraging Tolerance
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- Encouraging Tolerance
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- Lesson 5 Questions
Lesson 6 - Transplant Examples
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- Transplant Examples
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- Lesson 6 Questions
Quiz 6
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- Review Quiz 6
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- Quiz 6
Final
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- Course 3 Review
- Final
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- Farewell
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- End-of-Course Survey
Auto Summary
Explore the intricate workings of the immune system with "Fundamentals of Immunology: Death by Friendly Fire," a professional-level course offered by Coursera. Delve into adaptive and innate immunity, antibody functions, autoimmune diseases, and hypersensitivity reactions through engaging lectures, animations, and diagrams. Enhance your understanding of immune responses and disease prevention in this comprehensive 1620-minute course, available with various subscription options. Ideal for science and engineering enthusiasts seeking advanced knowledge in immunology, guided by expert instruction.