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Fundamentals of Immunology: Innate Immunity and B-Cell Function
  • Level Professional
  • المدة 16 ساعات hours
  • الطبع بواسطة Rice University
  • Offered by

عن

Course 1 of a three course specialization called Fundamentals of Immunology. Each course in the specialization presents material that builds on the previous course's material. This is the first leg of a three-part journey through the defenses your body uses to keep you healthy. In this part we hope to give you the vocabulary and concepts you need to interact with the medical community and to provide them in a context that makes them memorable. Fundamentals of Immunology introduces students to the basic functions of the adaptive and innate immune systems. The early lectures survey cells, tissues and organs using metaphors, cartoons and models to improve understanding and retention. After describing the form, function, origin and varieties of antibodies, subsequent lectures provide details on the mechanism of the generation of variation. The course provides animations of gene rearrangement and class switching and descriptions of affinity maturation correlated with detailed physical models of antibody structure. The final lecture reviews these concepts in anatomical context. Testing employs multiple choice questions testing facts, concepts, and application of principles. Questions may refer to diagrams, drawing and photographs used in lecture and reproduced in the outline. What You'll Learn: The difference between adaptive and innate immune systems, the characteristics of various pathogens that they protect you from and the overall strategies employed in this protection. The detailed structure of antibodies and related immunoglobulin receptors, the characteristics and function of the different antibody classes and the mechanism for producing both the recognition regions and stem regions.  Finally, how these structures are coded for in the DNA and expressed in the B cells.

الوحدات

Welcome

    • 1 Videos
    • 3 Readings
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  • Welcome

3 Readings

  • Course Information and Syllabus
  • Course Outline
  • Pre-Course Survey

Lesson 1- Introduction

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  • Context

Lesson 2 - Staying Healthy

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  • Lesson 2 Questions

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  • Staying Healthy

Lesson 3 - Pathogen Varieties

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  • Lesson 3 Questions

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  • Pathogen Varieties

Lesson 4 - Pathogen Recognition

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  • Lesson 4 Questions

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  • Pathogen Recognition

Lesson 5 - Words of Advice

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  • Lesson 5 Questions

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  • Words of Advice

Lesson 6 - Metaphors of Power Politics

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  • Lesson 6 Questions

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  • Metaphors of Power Politics

Lesson 7 - Innate Versus Defensive Responses

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  • Lesson 7 Questions

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  • Innate Versus Defensive Responses

Quiz 1

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  • Lecture 1 Practice Quiz
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Lesson 1 - Terminology

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  • Lesson 1 Questions

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  • Terminology

Lesson 2 - Hematopoiesis

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  • Hematopoiesis

Lesson 3 - Myeloid Granulocytes

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  • Lesson 3 Questions

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  • Myeloid Granulocytes

Lesson 4 - Myleolid Antigen Presenting Cells

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  • Lesson 4 Questions

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  • Myleolid Antigen Presenting Cells

Lesson 5 - Lymphocytes

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  • Lesson 5 Questions

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  • Lymphocytes

Lesson 6 - Primary Organs

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  • Lesson 6 Questions

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  • Primary Organs

Lesson 7 - Lymph: Fluid, Vessels and Nodes

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  • Lesson 7 Questions

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  • Lymph: Fluid, Vessels and Nodes

Lesson 8 - Other Secondary and Tertiary Organs

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  • Other Secondary and Tertiary Organs

Lesson 9 - Final Issues

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Quiz 2

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Lesson 1 - Basic Considerations

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Lesson 2 - Inflammation

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  • Inflammation

Lesson 3 - Innate Targeting of Pathogens

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  • Innate Targeting of Pathogens

Lesson 4 - Myeloid Cell Function

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  • Lesson 4 Questions

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  • Myeloid Cell Function

Lesson 5 - Innate and Adaptive Immunity Compared

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  • Innate and Adaptive Immunity Compared

Quiz 3

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  • Practice Quiz 3
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Lesson 1 - Context

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  • Context

Lesson 2 - The Immunoglobulin superfamily

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  • Lesson 2 Questions

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  • The Immunoglobulin Superfamily

Lesson 3 - Form and Function

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  • Lesson 4 Questions

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  • Form and Function

Lesson 4 - Immunoglobulin Classes

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  • Immunoglobulin Classes

Lesson 5 - Specific Ig Types

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  • Specific Ig Types

Lesson 6 - Immunoglobulins in Action

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  • Lesson 6 Questions

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  • Immunoglobulins in Action

Lesson 7 - Fc Biological Activity

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  • Fc Biological Activity

Lesson 8 - The B Cell Receptor

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  • Lesson 8 Questions

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  • The B Cell Receptor

Lesson 9 - Monoclonal Antibodies

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  • Monoclonal Antibodies

Quiz 4

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  • Practice Quiz 4
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Lesson 1 - Uniqueness of the System

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  • Uniqueness of the System

Lesson 2 - Scale and Models

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  • Scales and Models

Lesson 3 - Gene to RNA to Protein

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  • Gene to RNA to Protein

Lesson 4 - Light Chain Gene Expression

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Lesson 5 - Heavy Chain Gene Expression

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  • Heavy Chain Gene Expression

Lesson 6 - Rearrangement in Developmental Context

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  • Rearrangement in Developmental Context

Lesson 7 - Recombination Signal Sequence Structure

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  • Recombination Signal Sequence Structure

Lesson 8 - Mechanism Details

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  • Mechanism Details

Lesson 9 - Commitment to a Definite CDR

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  • Commitment to a Definite CDR

Lesson 10 - Generation of Antibody Diversity

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  • Generation of Antibody Diversity

Lesson 11 - Class Switching

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  • Class Switching

Lesson 12 - Synthesis and Secretion

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  • Synthesis and Secretion

Quiz 5

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  • Practice Quiz 5
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Lesson 1 - B Cell Maturation: Details and Review

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  • B Cell Maturation

Lesson 2 - Initial Steps in Bone Marrow: Review

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  • Initial Steps in Bone Marrow

Lesson 3 - Activation: Thymus Independent

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  • Activation: Thymus Independent

Lesson 4 - Primary and Secondary Responses: T cells

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  • Primary and Secondary Responses: T Cells

Lesson 5 - Anatomical and Histological Context

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  • Lesson 5 Questions

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  • Anatomical and Histological Context

Lesson 6 - Affinity Maturation

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  • Lesson 6 Questions

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  • Affinity Maturation

Lesson 7 - Final Decisions

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  • Lesson 7 Questions

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  • Final Decisions

Lesson 8 - Regulation

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  • Regulation

Quiz

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  • Practice Quiz 6
  • Quiz 6

Final

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  • Final Exam Review
  • Final Exam

1 Videos

  • Farewell

1 Readings

  • End-of-Course Survey

Auto Summary

Embark on an enlightening journey with "Fundamentals of Immunology: Innate Immunity and B-Cell Function," a comprehensive course designed to deepen your understanding of the immune system. This course is the first installment in a three-part specialization focused on building a robust knowledge base in immunology, perfect for professionals in the Science & Engineering domain. Led by expert instructors, this course blends engaging metaphors, cartoons, and models to introduce the critical functions of both adaptive and innate immune systems. Early lectures cover the cells, tissues, and organs involved in immunity, while subsequent sessions delve into the intricate details of antibody structures, their generation, and variation. You will gain insights into gene rearrangement, class switching, and affinity maturation, all illustrated through detailed animations and physical models. Throughout this course, you will learn to distinguish between adaptive and innate immune responses, understand the diverse pathogens they combat, and explore the sophisticated strategies employed by the immune system. By the end of the course, you will have mastered the detailed structure and function of various antibodies, their genetic coding, and expression in B cells. With a duration of 960 minutes, this professional-level course is ideal for anyone seeking to enhance their interaction with the medical community and solidify their immunology knowledge. Available through Coursera’s Starter subscription, it offers a flexible and accessible path to mastering the foundational concepts of immunology. Join us to gain the vocabulary and context needed to navigate the fascinating world of immune defenses.

Alma Moon Novotny, Ph.D.
Instructor

Alma Moon Novotny, Ph.D.