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Fundamentals of Immunology: T Cells and Signaling

عن

Course 2 of a three course specialization called Fundamentals of Immunology. Each course in the specialization presents material that builds on the previous course's material. This is the second half of the journey through the defenses your body uses to keep you healthy. In the first part we learned about innate immunity and B cell function. The second part covers T cell function and coordination of the immune response. Fundamentals of Immunology: T cells and Signaling builds on the first course to describe the functions of Complement, MHC presentation to T cells, T cell development and signaling. The early lectures survey cells, tissues and organs using metaphors, cartoons and models to improve understanding and retention. This course includes the structure of both MHC proteins and T cell receptors and the sources of variation. The course provides animations of gene rearrangement, developmental processes and signal cascades. Testing employs multiple choice questions testing facts, concepts, and application of principles. Questions may refer to diagrams, drawing and photographs used in lecture and reproduced in the outline. What You'll Learn: How complement uses adaptive and innate triggers to target pathogens. The detailed structure and coding of MHC proteins and both alpha-beta and gamma delta receptors and how these proteins interact to initiate an adaptive immune response. The basics of signaling, and the varieties of external receipt and internal activation pathways. We bine the process of putting together how signals and crosstalk control the activity of the immune system.

الوحدات

Welcome

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    • 2 Readings
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  • Welcome

2 Readings

  • Course Study Guide
  • Pre-Course Survey

Lesson 1 - Overview and Terminology

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  • Overview and Terminology

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Lesson 2 - Activation of MAC

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  • Activation of MAC

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Lesson 3 - Classical Pathway

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  • Classical Pathway

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Lesson 4 - Alternative Pathway

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  • Alternative Pathway

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Lesson 5 - Lectin Pathway

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  • Lectin Pathway

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Lesson 6 - Endgame and Consequences

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  • Endgame and Consequences

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Lecture 1 Quiz

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  • Lecture 1 Practice Quiz
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Lesson 1 - MHC Genes

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  • MHC Genes

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Lesson 2 - MHC Haplotypes

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  • MHC Haplotypes

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Lesson 3 - Inbreeding

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  • Inbreeding

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Lesson 4 - MHC Protein Structure

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  • MHC Protein Structure

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Lesson 5 - Specifics of Peptide Binding

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  • Specifics of Peptide Binding

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Lesson 6 - MHC Genetic Expression

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  • MHC Genetic Expression

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Lesson 7 - Non-Classical Alleles

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  • Non-Classical Alleles

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Lesson 8 - MHC and Disease

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  • MHC and Disease

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Lecture 2 Quiz

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  • Lecture 2 Practice Quiz
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Lesson 1 - T Cell Antigen Recognition

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  • T Cell Antigen Recognition

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Lesson 2 - Self-MHC Restriction

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  • Self-MHC Restriction

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Lesson 3 - The Cytosolic Pathway

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  • The Cytosolic Pathway

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Lesson 4 - Exogenous Pathway

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  • The Exogenous Pathway

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Lesson 5 - Variations

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  • Variations

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Lesson 6 - Comparisons and Questions

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Lecture 3 Quiz

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Lesson 1 - Early Work

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Lesson 2 - Structure and Roles

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Lesson 3 - T-cell Receptor Genes

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  • T-cell Receptor Genes

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Lesson 4 - Gene Rearrangement - αβ genes

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  • Gene Rearrangement: αβ genes

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Lesson 5 - Gene Rearrangement: γδ genes

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  • Gene Rearrangement: γδ genes

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Lesson 6 - Diversity and its Constraints

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  • Diversity and its Constraints

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Lesson 7 - The TCR Receptor Complex

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  • The TCR Receptor Complex

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Lesson 8 - Alloreactivity

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Lecture 4 Quiz

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Lesson 1 - Into the Thymus

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  • Into the Thymus

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Lesson 2 - Double Negative Transitions

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Lesson 3 - Double Positive Event: Positive Selection

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  • Double Positive Event: Positive Selection

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Lesson 4 - Negative Selection

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  • Negative Selection

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Lesson 5 - CD4+ Varieties

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  • CD 4+ Varieties

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Lesson 6 - Activation

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  • Activation

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Lecture 5 Quiz

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Lesson 1 - Information Transfer

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Lesson 2 - Fundamental Signals

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Lesson 3 - Contributory Signals

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  • Contributory Signals

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Lesson 4 - Common Themes in Signaling

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  • Common Themes in Signaling

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Lesson 5 - Signaling and TH Subsets

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  • Signaling and TH Subsets

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Lesson 6 - Determining the TH Subsets

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  • Determining the TH Subsets

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Lesson 7 - Clinical Applications

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  • Clinical Applications

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Lecture 6 Quiz

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  • Lecture 6 Quiz

Final

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  • Farewell

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  • End-of-Course Survey

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  • Final

Auto Summary

"Fundamentals of Immunology: T Cells and Signaling" is the second course in a specialized Science & Engineering series, led by Coursera. This professional-level course delves into T cell function and immune response coordination, building on prior knowledge of innate immunity and B cell function. Through engaging metaphors, animations, and models, learners explore MHC presentation, T cell development, and signaling pathways. The course spans 1560 minutes and offers multiple subscription options, catering to those seeking to deepen their understanding of immunology. Ideal for professionals, it emphasizes practical applications and interactive learning.