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Introduction to Systems Biology
  • Level Foundation
  • المدة 19 ساعات hours
  • الطبع بواسطة Icahn School of Medicine at Mount Sinai
  • Offered by

عن

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate "how" cell- level functions arise and "why" mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

الوحدات

Overview

    • 1 Videos
    • 1 Readings
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1 Videos

  • Overview of Systems Level Reasoning & Molecules to Pathways

1 Readings

  • Required Reading List

Systems Level Reasoning

    • 2 Videos
    • 1 Readings
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2 Videos

  • Systems Level Reasoning I
  • Systems Level Reasoning II

1 Readings

  • Lecture Slides

Molecules to Pathways

    • 2 Videos
    • 1 Readings
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2 Videos

  • Molecules to Pathways - cAMP and G Protein Pathways I
  • Molecules to Pathways - cAMP and G Protein Pathways II

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Systems Level Reasoning | Molecules to Pathways

Pathways to Networks

    • 2 Videos
    • 1 Readings
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2 Videos

  • Pathways to Networks - MAP-kinase Pathways/Network I
  • Pathways to Networks - MAP-kinase Pathways/Network II

1 Readings

  • Lecture Slides

Mechanical Forces in Cell Biology

    • 1 Videos
    • 1 Readings
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1 Videos

  • Mechanical Forces in Cell Biology

1 Readings

  • Lecture Slides

Electrical Activity in Cell Biology

    • 1 Videos
    • 1 Readings
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1 Videos

  • Electrical Activity in Cell Biology

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Pathways to Networks | Physical Forces and Electrical Activity in Cell Biology

Mathematical Representations of Cell Biological Systems I

    • 1 Videos
    • 1 Readings
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1 Videos

  • Mathematical Representations of Cell Biological Systems I

1 Readings

  • Lecture Slides

Mathematical Representations of Cell Biological Systems II

    • 1 Videos
    • 1 Readings
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1 Videos

  • Mathematical Representations of Cell Biological Systems II

1 Readings

  • Lecture Slides

Simulations of Cell Biological Systems

    • 2 Videos
    • 1 Readings
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2 Videos

  • Simulations of Cell Biological Systems I
  • Simulations of Cell Biological Systems II

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Mathematical Representations of Cell Biological Systems | Simulations of Cell Biological Systems

Experimental Technologies

    • 1 Videos
    • 1 Readings
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1 Videos

  • Experimental Technologies

1 Readings

  • Lecture Slides

Analyzing Large Data Sets

    • 1 Videos
    • 1 Readings
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1 Videos

  • Analyzing Large Data Sets

1 Readings

  • Lecture Slides

Network Building/Analysis and Data Organization

    • 1 Videos
    • 1 Readings
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1 Videos

  • Network Building/Analysis and Data Organization

1 Readings

  • Lecture Slides

Building Networks

    • 1 Videos
    • 1 Readings
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1 Videos

  • Building Networks

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Experimental Technologies | Network Building and Analysis

Midterm

    • 1 Assignment
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1 Assignment

  • Midterm Exam

Analysis of Networks

    • 2 Videos
    • 1 Readings
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2 Videos

  • Analysis of Networks I
  • Analysis of Networks II

1 Readings

  • Lecture Slides

From Topology to Function: Directed Sign Specified Graphs I

    • 1 Videos
    • 1 Readings
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1 Videos

  • From Topology to Function: Directed Sign Specified Graphs I

1 Readings

  • Lecture Slides

From Topology to Function: Directed Sign Specified Graphs II

    • 1 Videos
    • 1 Readings
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1 Videos

  • From Topology to Function: Directed Sign Specified Graphs II

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Analysis of Networks | Topology to Function

Strengths and Limitations of Different Types of Models I

    • 1 Videos
    • 1 Readings
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1 Videos

  • Strengths and Limitations of Different Types of Models I

1 Readings

  • Lecture Slides

Strengths and Limitations of Different Types of Models II

    • 1 Videos
    • 1 Readings
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1 Videos

  • Strengths and Limitations of Different Types of Models II

1 Readings

  • Lecture Slides

Identifying Emergent Properties: Bistability I

    • 1 Videos
    • 1 Readings
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1 Videos

  • Identifying Emergent Properties: Bistability I

1 Readings

  • Lecture Slides

Identifying Emergent Properties: Bistability II

    • 1 Videos
    • 1 Readings
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1 Videos

  • Identifying Emergent Properties: Bistability II

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Strengths and Limitations of Different Types of Models | Identifying Emergent Properties

Ultrasensitivity

    • 1 Videos
    • 1 Readings
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1 Videos

  • Ultrasensitivity

1 Readings

  • Lecture Slides

Robustness and Scaffolds

    • 1 Videos
    • 1 Readings
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1 Videos

  • Robustness and Scaffolds

1 Readings

  • Lecture Slides

Case Studies I

    • 1 Videos
    • 1 Readings
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1 Videos

  • Case Studies I

1 Readings

  • Lecture Slides

Case Studies II

    • 1 Videos
    • 1 Readings
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1 Videos

  • Case Studies II

1 Readings

  • Lecture Slides

Review

    • 1 Assignment
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1 Assignment

  • Emergent Properties: Ultrasensitivity and Robustness | Case Studies

Case Studies III

    • 1 Videos
    • 1 Readings
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1 Videos

  • Case Studies III

1 Readings

  • Lecture Slides

Case Studies IV

    • 1 Videos
    • 1 Readings
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1 Videos

  • Case Studies IV

1 Readings

  • Lecture Slides

Systems Biomedicine

    • 1 Videos
    • 1 Readings
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1 Videos

  • Systems Biomedicine

1 Readings

  • Lecture Slides

Systems Pharmacology and Therapeutics

    • 1 Videos
    • 1 Readings
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1 Videos

  • Systems Pharmacology and Therapeutics

1 Readings

  • Lecture Slides

Perspective

    • 1 Videos
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1 Videos

  • Perspective

Review

    • 1 Assignment
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1 Assignment

  • Case Studies | Systems Biomedicine | Systems Pharmacology and Therapeutics | Perspective

Final Exam

    • 1 Assignment
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1 Assignment

  • Final Exam

Auto Summary

Dive into the fascinating world of contemporary Systems Biology with this foundational course focused on mammalian cells and their functions. Led by expert instructors on Coursera, you'll explore molecular interactions, subcellular processes, and cellular behaviors through multivariable experiments, quantitative reasoning, and simulations. Ideal for learners in Science & Engineering, the course spans 1140 minutes and offers Starter, Professional, and Paid subscription options.

Ravi Iyengar, PhD
Instructor

Ravi Iyengar, PhD