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Non-Alcoholic Fatty Liver Disease – The Essentials
  • Level Professional
  • المدة
  • الطبع بواسطة University of Copenhagen
  • Offered by

عن

Non-Alcoholic Fatty Liver Disease (NAFLD) is a global problem, affecting up to 25% of all individuals. The disease not only increases the risk of liver disease, but also of cardiovascular disease and liver cancer. During this course, you will learn the essentials of NAFLD. We will begin with an introduction to the physiology of the human liver followed by epidemiology, pathophysiology, clinical medicine, and genetics. Diagnosing NAFLD based on blood tests, diagnostic imaging and histology will be discussed. Complications and treatment options will also be covered in this course including the link between NAFLD and the development of diabetes. Finally, experts will discuss data driven identification of new biomarkers by omics technologies. After completing this course, you will have a broad knowledge about NAFLD ranging from the aetiology and pathophysiology to bedside examinations and treatments.

الوحدات

Week 1

    • 5 Videos
    • 2 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Week 1

1 Discussions

  • The role of the metabolic homeostasis

5 Videos

  • The Liver – Our Most Important Organ
  • Anatomy and Function of the Liver
  • The Liver and Bile Acids
  • The Liver Controls Body Metabolism
  • Introduction to NAFLD

2 Readings

  • Physiology of the liver
  • Clinical Practice Guidelines for the management of NAFLD

Week 2

    • 3 Videos
    • 5 Readings
    • 1 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Week 2

1 Discussions

  • Focus on lifestyle interventions for treatment, yes or no?

3 Videos

  • Epidemiology
  • Nutrients and Insulin Resistance
  • Genetics

5 Readings

  • Fibrosis stage and mortality in NAFLD
  • Are Lifestyle Therapies Effective for NAFLD Treatment?
  • Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet
  • Role of Carbohydrate and Energy Availability
  • Genetic Aspects of NAFLD

Week 3

    • 3 Videos
    • 2 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Week 3

1 Discussions

  • The pathophysiology of NAFLD

3 Videos

  • Pathophysiology
  • The Multiple-Hit Hypothesis
  • Impact on Liver Function

2 Readings

  • The role of macrophages in NAFLD and NASH (abstract only)
  • NAFLD causes dissociated changes in metabolic liver functions

Week 4

    • 5 Videos
    • 3 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Week 4

1 Discussions

  • Diagnose NAFLD or just calculate the BMI?

5 Videos

  • Diagnostics – The Basic Terms
  • Blood Tests and Imaging
  • Histology
  • Mass-Spectrometry Based Diagnostics and Other Omics Technologies
  • Mass-Spectrometry Based Proteomics

3 Readings

  • Interpreting diagnostic accuracy studies for patient care
  • Noninvasive assessment of liver disease in patients with NAFLD
  • Design and validation of a histological scoring system for NAFLD

Diagnostic procedures – brief videos

    • 5 Videos
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5 Videos

  • Ultrasound
  • Liver Biopsy
  • Transjugular Liver Biopsy
  • Diagnostic and Therapeutic Paracenthesis
  • Assessment of Hepatic Encephalopathy

Week 5

    • 4 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Week 5

1 Discussions

  • Is it enough to lose weight to treat NAFLD?

4 Videos

  • Life-Style Interventions
  • Exercise Your Liver
  • Patient Relevant Outcomes
  • Pharmacological Treatment

1 Readings

  • Effects of Moderate and Vigorous Exercise on NAFLD: A Randomized Clinical Trial

Week 6

    • 4 Videos
    • 3 Readings
    • 1 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Week 6

1 Discussions

  • Focus on early stages of NAFLD rather than NASH-cirrhosis? 

4 Videos

  • NASH Cirrhosis
  • Complications to NASH Cirrhosis
  • NAFLD and Type 2 Diabetes
  • What We Learned

3 Readings

  • CLIF Consortium Acute Decompensation score (Abstract only)
  • Acute-on-chronic liver failure
  • NAFLD: a multisystem disease

Auto Summary

Explore the essentials of Non-Alcoholic Fatty Liver Disease (NAFLD) in this comprehensive course by Coursera. Ideal for professionals in Science & Engineering, it covers liver physiology, epidemiology, pathophysiology, diagnostics, complications, and treatments. Learn from experts about biomarkers and omics technologies. Available through Starter and Professional subscriptions.

Nicolai Jacob Wewer Albrechtsen
Instructors

Nicolai Jacob Wewer Albrechtsen

Lise Lotte Gluud
Instructors

Lise Lotte Gluud