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Precision Medicine
  • Level Professional
  • المدة 29 ساعات hours
  • الطبع بواسطة University of Geneva
  • Offered by

عن

This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues. From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health. Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers. Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations. Whether you are interested or intrigued by topics such as “genethics”, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine. - update - The contents of this course have been updated and important corrections have been implemented thanks to learners' feedback. Many thanks to them!

الوحدات

Welcome to the course

    • 2 Videos
    • 4 Readings
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2 Videos

  • Trailer
  • Welcome to the course

4 Readings

  • 📢 Important preliminary information: Evaluations and subtitles
  • Syllabus
  • List of Teachers
  • Bibliographic References

Introduction to monogenic disorders

    • 1 Videos
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1 Videos

  • Introduction to the module

Human genome variability and phenotype consequences

    • 2 Videos
    • 1 Assignment
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1 Assignment

  • Human genome variability and phenotype consequences

2 Videos

  • Human genome variabilty and phenotype consequences 1
  • Human genome variability and phenotype consequences 2

Case study

    • 4 Videos
    • 2 Assignment
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2 Assignment

  • Medical consultation part 1
  • Exome sequencing analysis

4 Videos

  • Medical consultation (part 1)
  • Exome sequencing analysis
  • What are the options? discussion between the physician and the biologist
  • Medical consultation (part 2)

Monogenic disorders: challenges and perspectives

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Rare genetic disorder and precision medicine

1 Videos

  • Rare genetic disorder and precision medicine

Genethics

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Ethical, Legal and Social Implications (ELSI)

1 Videos

  • Ethical, Legal and Social Implications (ELSI)

Conclusion of Module 1

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Monogenic disease

1 Videos

  • Conclusion

1 Readings

  • 📢 Important preliminary information: Evaluations and subtitles

Introduction

    • 1 Videos
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1 Videos

  • Introduction

Genetics of complex disorders

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Genetics of complex disorders

1 Videos

  • Genetics of complex disorders

Environmental determinant

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Environmental determinants

1 Videos

  • Environmental determinant

Case study - part 1, current approaches

    • 3 Videos
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • How to evaluate the disease risk (part 1)

1 Discussions

  • Diabetes management today

3 Videos

  • Diabetes management today
  • Diabetes risk assessment part 1
  • The key points - answers to the discussion by the expert (part 1)

Case study - part 2, future approaches

    • 3 Videos
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • How to evaluate the disease risk (part 2)

1 Discussions

  • Precision approches in diabetes

3 Videos

  • Precision approaches in diabetes
  • Diabetes risk assessment (part 2)
  • The key points - answers to the discussion by the expert (part 2)

Conclusion

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Complex disease

1 Videos

  • Conclusion

Introduction

    • 4 Videos
    • 3 Assignment
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3 Assignment

  • Sommatic mutation theory of cancer
  • Synthetic lethality and oncogene addiction
  • Introduction to clinical ethics

4 Videos

  • Somatic mutation theory of cancer
  • Synthetic lethality and oncogene addiction
  • Clinically-orientated analysis
  • Introduction to clinical ethics

Implementation of precision oncology

    • 6 Videos
    • 6 Assignment
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6 Assignment

  • Objectives of precision oncology
  • Tumor classification
  • What is a biomarker?
  • Somatic bioinformatics pipeline
  • Molecular tumor board
  • Ethical and societal implications

6 Videos

  • Objectives of precision oncology
  • Tumor classification
  • What is a biomarker?
  • Somatic bioinformatics pipelines
  • Molecular tumor board
  • Ethical and societal implications

Oncogenetics

    • 4 Videos
    • 4 Assignment
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4 Assignment

  • Sporadic, familial and hereditary cancer
  • Family history in oncology
  • Genetic counselling in oncology
  • Main hereditary cancer syndromes

4 Videos

  • Sporadic, familial and hereditary cancer
  • Family history in oncology
  • Genetic counselling in oncology
  • Main hereditary cancer syndromes

Case studies

    • 4 Videos
    • 3 Assignment
Show info about module content

3 Assignment

  • Case Study 1 - part 1
  • Case Study 1 - part 2
  • Case Study 2 - part 1

4 Videos

  • Case study 1 - part 1
  • Case study 1 - part 2
  • Case study 2 - part 1
  • Case study 2 - part 2

Conclusion

    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Cancer

1 Readings

  • Further reading

Welcome to the module

    • 1 Videos
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1 Videos

  • Introduction to the module

Introduction

    • 3 Videos
    • 2 Assignment
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2 Assignment

  • Testing the opportunities discussed
  • Testing the illustration discussed

3 Videos

  • The Revolution of Genetic Technologies
  • Main Opportunities of Genomics
  • Genomics and Complex Chronic Diseases

Interaction

    • 3 Videos
    • 1 Readings
    • 3 Assignment
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3 Assignment

  • Testing the concept of behaviome
  • Testing the understanding of the Tyrell and all. results
  • Big Data

3 Videos

  • The Revolution of Environmental Technologies
  • Genome-Exposome Interaction
  • Big Data

1 Readings

  • Tyrell and all.

Challenges of translating genomics into clinical care

    • 2 Videos
    • 1 Assignment
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1 Assignment

  • Testing challenges of translating genomics into clinical care

2 Videos

  • Validity and Massive Information
  • Restitution, Unintended Findings and Actionable Variants

Key role of primary care physician in the era of precision medicine

    • 2 Videos
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2 Videos

  • Patients' Willingness to Discuss their Genomic Information
  • Evidence-Based Precision Medicine

Conclusion

    • 2 Videos
    • 1 Assignment
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1 Assignment

  • Health and prevention

2 Videos

  • Conclusion
  • New Technologies and Personalized Health: Opportunities and Challenges

General principles in pharmacogenetics

    • 4 Videos
    • 3 Assignment
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3 Assignment

  • Variability in drug response
  • Drug metabolism
  • Role of Transporters in Drug Disposition

4 Videos

  • Introduction to the module
  • Variability in drug response
  • Drug metabolism
  • Role of Transporters in Drug Disposition

Pharmacogenomics and cardiovascular medicine

    • 2 Videos
    • 2 Assignment
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2 Assignment

  • Pharmacogenomics of statins
  • Other cardiovascular diseases

2 Videos

  • Case - Pharmacogenomics of Statins
  • Other Cardiovascular Case Studies

Pharmacogenomics and pain

    • 2 Videos
    • 2 Readings
    • 2 Assignment
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2 Assignment

  • Pharmacogenomics of opioids
  • Tools of clinicians and patients

2 Videos

  • Pharmacogenomics of opioids
  • Tools for clinicians and patients

2 Readings

  • Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
  • Table of Pharmacogenetic Associations

Lab tools to support personalized therapy and pharmacogenomics

    • 2 Videos
    • 2 Readings
    • 2 Assignment
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2 Assignment

  • Current Methods to Identify Pharmacogenomics Variants
  • Phenotyping in the lab

2 Videos

  • Current Methods to Identify Pharmacogenomics Variants
  • Phenotyping in the lab

2 Readings

  • Case study: antiaggregant and HIV
  • Case Study: the example of oxycodone

Pharmacogenomics and drug development

    • 4 Videos
    • 4 Assignment
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4 Assignment

  • Drug development 1
  • Drug development 2
  • Pharmacovigilance
  • Pharmacoeconomics and pharmacogenomics

4 Videos

  • Drug development 1
  • Drug development 2
  • Pharmacovigilance
  • Pharmacoeconomics of pharmacogenomics

Blockchain and data deidentification

    • 2 Videos
    • 2 Assignment
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2 Assignment

  • Citizen Centered Consent
  • Data Deidentification

2 Videos

  • Citizen Centered Consent
  • Data deidentification

Conclusion

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Pharmacogenomics and Drug Development

1 Videos

  • Conclusion and Future Perspectives

Introduction

    • 1 Videos
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1 Videos

  • Introduction to the module

Precision medicine research project

    • 4 Videos
    • 3 Assignment
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3 Assignment

  • First steps of a research project
  • Sample collection, biobanking and data generation/recording
  • On Data videos above (2)

4 Videos

  • First Steps of a Research Project
  • Sample Collection, Biobanking and Data Generation/Recording
  • Data Quality Control and Data Analysis
  • Data dissemination, databases and publication

Example of a precision medicine project (part 1)

    • 1 Videos
    • 2 Readings
    • 2 Assignment
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2 Assignment

  • Questions on published article
  • Questions on abstract

1 Videos

  • Explanations by the expert

2 Readings

  • Estimating the causal tissues for complex traits and diseases
  • Abstract section of the article

Example of a precision medicine research project (part 2)

    • 2 Videos
    • 2 Assignment
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2 Assignment

  • Patient stratification in traumatic brain injury
  • Steroid signatures in toxicology

2 Videos

  • Explanation by the expert: patient stratification in traumatic brain injury
  • Explanations by the expert: Steroid Signatures in Toxicology

Conclusion

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Research

1 Videos

  • Conclusion of the module

Thank you for joining us

    • 1 Videos
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1 Videos

  • Conclusion of the course in Precision Medicine

Auto Summary

Explore the dynamic world of precision medicine with this comprehensive course designed for life sciences graduates and professionals. Delve into diagnostics, treatment selection, genetic counseling, public health, and biomedical research. Learn from experts in genetics, genomics, oncology, pharmacology, data science, and ethics. This 1740-minute course, provided by Coursera, offers practical examples and clinical case studies, suitable for primary care physicians, healthcare professionals, policymakers, and researchers. Available with Starter and Professional subscription options, this course equips you with the knowledge to excel in the evolving field of precision medicine.

Antoine Geissbuhler
Instructors

Antoine Geissbuhler

Idris Guessous
Instructors

Idris Guessous

Caroline Samer
Instructors

Caroline Samer

Christelle Borel
Instructors

Christelle Borel

Petros Tsantoulis
Instructors

Petros Tsantoulis