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Personalised Medicine from a Nordic Perspective
  • Level Professional
  • المدة 14 ساعات hours
  • الطبع بواسطة University of Copenhagen
  • Offered by

عن

The technical revolution has generated large amounts of data in healthcare and research, and a rapidly increasing knowledge about factors of importance for the individual’s health. This holds great potential to support a change from the one-size-fits-all paradigm to personalised or precision medicine, to guide and thereby improve each health decision of expected benefit for the patient. The SARS-CoV-2 pandemic has contributed to a great public and political awareness of the importance of personalised medicine, where the influence of host factors like age, sex, obesity, smoking, co-morbidities etc. confer increased risk of serious COVID-19 illness. It is expected that in the near future, a more systematic and data-driven approach for prediction and risk stratification of COVID-19 patients and many other patient groups, will increase and improve due to better understanding of disease pathology, including the influence of genetic variability and biomarkers on disease risk and outcome. The Nordic countries have unique welfare systems with general access to healthcare, and longitudinal nationwide health databases and biobanks. This infrastructure combined with unique person identifiers creates an optimal setting for personalised medicine development, and the Nordic model of research, translation, care and education can serve as a forefront example for the rest of the world. The course in Personalised medicine from a Nordic perspective will introduce, describe, define and discuss the concept of personalised medicine from the aspect of the patient, health-care and the infrastructure available to generate a learning environment that is integrated with everyday care of patients. The course also covers communication of risk and the ethical, legal and social aspects of personalised medicine and presents examples where personalised medicine approach is already used in routine care. The course was initiated by Faculty leaders in the Education Working Group of Nordic Medical Schools and received funding from the Joint Committee of the Nordic Medical Research Councils (NOS-M). Experts from all the Nordic countries participate in the course: Saedis Saevarsdottir, Sisse Ostrowski, Hans Tomas Björnsson, Richard Rosenquist Brandell, Henning Bundgaard, Engilbert Sigurðsson, Aarno Palotie, Ole A Andreassen, Runolfur Palsson, Alma Möller, Søren Brunak, Johan Askling, Carsten Utoft Niemann, Rudi Agius, Sofia Ernestam, Saemundur Oddsson, Henrik Ullum, Kari Stefansson, Patrick Sulem, Simon Rasmussen, Jens Lundgren, Anders Perner, Merete Lund Hetland, Heidi Bentzen, Henning Langberg, Sigurdur Kristinsson, Thor Aspelund, Jeanette Knox, David Arnar, Sigurdis Haraldsdottir, Hakon Heimer, Lone Frank, Mette Nordahl Svendsen, Bjorn Hofmann, and Morten Søgaard.

الوحدات

Welcome to the course

    • 1 Videos
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1 Videos

  • Introduction to Personalised Medicine from a Nordic Perspective – Saedis Saevarsdottir, Sisse Ostrowski

Applied examples

    • 1 Videos
    • 1 Readings
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1 Videos

  • Applied examples – Hans Tomas Björnsson, Richard Rosenquist Brandell, Henning Bundgaard

1 Readings

  • Further reading

What is personalised medicine?

    • 1 Videos
    • 3 Readings
    • 1 Assignment
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1 Assignment

  • What is personalised medicine?

1 Videos

  • What is personalised medicine? – Sisse Ostrowski

3 Readings

  • Precision medicine: discovering clinically relevant and mechanistically anchored disease subgroups at scale
  • Classification, ontology, and precision medicine
  • Further reading

Why the Nordic perspective?

    • 1 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Why the Nordic perspective?

1 Discussions

  • Challenges and opportunities in your country

1 Videos

  • Why the Nordic perspective? – Saedis Saevarsdottir

1 Readings

  • Further reading

Initiatives to address unmet needs in common diseases

    • 1 Videos
    • 1 Readings
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1 Videos

  • (Suited for listening) Initiatives to address common diseases – Engilbert Sigurðsson, Aarno Palotie, Ole A Andreassen, Runolfur Palsson

1 Readings

  • Further reading

What is health data? Data generation pre-birth and throughout life

    • 1 Videos
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1 Videos

  • What is health data? Data generation pre-birth and throughout life – Alma Möller

Patient information used to generate personalised medicine

    • 1 Videos
    • 2 Readings
    • 1 Assignment
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1 Assignment

  • Patient information used to generate personalised medicine

1 Videos

  • Patient information used to generate personalised medicine – Johan Askling

2 Readings

  • Patient-reported outcomes in the Swedish National Quality Registers
  • Patient-reported outcome and experience measures

Optimizing clinical decision making with data-driven approaches

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Optimizing clinical decision making with data-driven approaches

1 Videos

  • Optimizing clinical decision making with data-driven approaches – Carsten Utoft Niemann

1 Readings

  • Real-world data-driven machine learning in CLL

Data cleaning and validation

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Data cleaning and validation

1 Videos

  • Data cleaning and validation – Rudi Agius

1 Readings

  • Further reading

Mapping disease trajectories from longitudinal health data

    • 1 Videos
    • 2 Readings
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1 Videos

  • Mapping disease trajectories from longitudinal health data – Søren Brunak

2 Readings

  • Time-ordered comorbidity correlations
  • Further reading

Digital tools for patient engagement

    • 1 Videos
    • 2 Readings
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1 Videos

  • Digital tools for patient engagement – Sofia Ernestam, Saemundur Oddsson

2 Readings

  • Optional: Explore the digital tools
  • Communicating polygenic and non-genetic risk...

What is a biomarker?

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • What is a biomarker?

1 Videos

  • What is a biomarker? – Saedis Saevarsdottir

1 Readings

  • Further reading

Studying and implementing useful biomarkers in clinical practice

    • 1 Videos
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1 Videos

  • Studying and implementing useful biomarkers in clinical practice – Henrik Ullum, Henning Bundgaard

Clinical sequencing and genetic testing – ‘science fiction’ a few years ago

    • 1 Videos
    • 1 Plugin
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1 Videos

  • (Suited for listening) Clinical sequencing and genetic testing – 'science fiction' a few years ago – Hans Tomas Björnsson, Patrick Sulem

Omics and beyond – smart ways to identify biomarkers

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Omics and beyond - smart ways to identify biomarkers

1 Videos

  • Omics and beyond – smart ways to identify biomarkers – Simon Rasmussen

1 Readings

  • Multi-omics approaches to disease

The use of genetic information in clinical medicine

    • 1 Videos
    • 1 Readings
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1 Videos

  • The use of genetic information in clinical medicine – David O. Arnar

1 Readings

  • Unexplained sudden death: next-generation sequencing to the rescue?

What is evidence? Shift in the paradigm driven by personalised medicine

    • 1 Videos
    • 2 Readings
    • 1 Assignment
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1 Assignment

  • What is evidence? Shift in paradigm driven by personalised medicine

1 Videos

  • What is evidence? Shift in paradigm driven by personalised medicine – Jens Lundgren

2 Readings

  • Evidence-based medicine: What it is and what it isn't
  • Further reading

Novel trials to generate evidence

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Novel trials to generate evidence

1 Videos

  • Novel trials to generate evidence – Merete Lund Hetland, Anders Perner

1 Readings

  • Further reading

How to generate evidence from a legal and ethical perspective

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • How to generate evidence from a legal and ethical perspective

1 Videos

  • How to generate evidence from a legal and ethical perspective – Heidi Bentzen

1 Readings

  • Further reading

Innovation: From research to clinical practice

    • 1 Videos
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1 Videos

  • Innovation: From research to clinical practice – Henning Langberg

Screening for rare and common diseases

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Screening for rare and common diseases

1 Videos

  • Screening for rare and common diseases – Sigurdur Kristinsson

How to communicate risk

    • 1 Videos
    • 3 Readings
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1 Videos

  • How to communicate risk – Thor Aspelund

3 Readings

  • Helping patients decide: Ten steps to better risk communication
  • Five ways to communicate risks so that patients understand
  • Further reading

Patient-centred care as a complement to personalised medicine

    • 1 Videos
    • 3 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Patient-centred care as a complement to personalised medicine

1 Discussions

  • Patient-centered care and personalised medicine

1 Videos

  • Patient-centered care as a complement to personalised medicine – Jeanette Knox

3 Readings

  • The difference that kind and compassionate care makes
  • The art of radical listening
  • Further reading

Diagnosed with a risk variant?

    • 1 Videos
    • 1 Readings
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1 Videos

  • Diagnosed with a risk variant? – Sigurdis Haraldsdottir

1 Readings

  • Further reading

Media hype and horror

    • 1 Videos
    • 1 Discussion
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1 Discussions

  • Personalised Medicine – Media hype and horror

1 Videos

  • Media hype and horror – Hakon Heimer, Lone Frank, Heidi Bentzen

Ethical concerns

    • 1 Videos
    • 1 Assignment
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1 Assignment

  • Ethical concerns

1 Videos

  • Ethical concerns – Mette Nordahl Svendsen

Legal regulation

    • 1 Videos
    • 1 Readings
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1 Videos

  • Legal regulation – Heidi Bentzen

1 Readings

  • Further reading

Ethical and social aspects

    • 1 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Ethical and social aspects

1 Videos

  • Ethical and social aspects – Bjørn Hofmann

1 Readings

  • Further reading

Why does industry invest in genetics and omics

    • 2 Videos
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2 Videos

  • (Suited for listening) Morten Søgaard, Pfizer – Why invest in genetics and omics
  • (Suited for listening) Kari Stefansson, deCODE genetics – Why invest in genetics and omics

Reflections on the future

    • 1 Videos
    • 1 Readings
    • 1 Discussion
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1 Discussions

  • Course reflection and looking ahead

1 Videos

  • Reflections on the future – Saedis Saevarsdottir, Sisse Ostrowski

1 Readings

  • Further reading

Other great learning resources and add you own

    • 1 Discussion
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1 Discussions

  • Other great learning resources – and add your own

Auto Summary

Explore the transformative power of data in healthcare with "Personalised Medicine from a Nordic Perspective." This professional-level course delves into the shift from a one-size-fits-all approach to precision medicine, emphasizing the unique healthcare infrastructure of Nordic countries. Led by a panel of Nordic experts, it covers predictive data use, ethical considerations, and real-world applications. Perfect for healthcare professionals, the course spans 840 minutes and offers a starter subscription on Coursera. Join to understand how personalized medicine can enhance patient care globally.

Sisse Rye Ostrowski
Instructors

Sisse Rye Ostrowski

Saedis Saevarsdottir
Instructors

Saedis Saevarsdottir