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Genome Sequencing (Bioinformatics II)
You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics.
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Course by
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Self Paced
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18 ساعات
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الإنجليزية
Julia Scientific Programming
This course introduces you to Julia as a first programming language. Julia is a high-level, high-performance dynamic programming language developed specifically for scientific computing. This language will be particularly useful for applications in physics, chemistry, astronomy, engineering, data science, bioinformatics, and many more.
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Course by
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Self Paced
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19 ساعات
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الإنجليزية
Network Analysis in Systems Biology
This course introduces data analysis methods used in systems biology, bioinformatics, and systems pharmacology research. The course covers methods to process raw data from genome-wide mRNA expression studies (microarrays and RNA-seq) including data normalization, clustering, dimensionality reduction, differential expression, enrichment analysis, and network construction. The course contains practical tutorials for using several bioinformatics tools and setting up data analysis pipelines, also covering the mathematics behind the methods applied by these tools and workflows.
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Course by
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Self Paced
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30 ساعات
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الإنجليزية
Hacking COVID-19 — Course 2: Decoding SARS-CoV-2's Secrets
In this course, you will follow in the footsteps of the bioinformaticians investigating the COVID-19 outbreak by annotating the SARS-CoV-2 genome and using the annotation to design a COVID-19 diagnostic test. Whether you’re new to the world of computational biology, or you’re a bioinformatics expert seeking to learn about its applications in the COVID-19 pandemic, or somewhere in between, this course is for you!
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Course by
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Self Paced
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الإنجليزية
Plant Bioinformatics
The past 15 years have been exciting ones in plant biology. Hundreds of plant genomes have been sequenced, RNA-seq has enabled transcriptome-wide expression profiling, and a proliferation of "-seq"-based methods has permitted protein-protein and protein-DNA interactions to be determined cheaply and in a high-throughput manner. These data sets in turn allow us to generate hypotheses at the click of a mouse. For instance, knowing where and when a gene is expressed can help us narrow down the phenotypic search space when we don't see a phenotype in a gene mutant under "normal" growth conditions.
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Course by
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Self Paced
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14 ساعات
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الإنجليزية
Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen
In this course, you will follow in the footsteps of the bioinformaticians investigating the COVID-19 outbreak by assembling the SARS-CoV-2 genome. Whether you’re new to the world of computational biology, or you’re a bioinformatics expert seeking to learn about its applications in the COVID-19 pandemic, or somewhere in between, this course is for you! As you go through this journey, we will introduce and explain genomic concepts and give you many opportunities to practice your skills, and we will provide a series of problems with gradually increasing complexity.
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Course by
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Self Paced
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الإنجليزية
Big Data, Genes, and Medicine
This course distills for you expert knowledge and skills mastered by professionals in Health Big Data Science and Bioinformatics. You will learn exciting facts about the human body biology and chemistry, genetics, and medicine that will be intertwined with the science of Big Data and skills to harness the avalanche of data openly available at your fingertips and which we are just starting to make sense of.
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Course by
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Self Paced
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40 ساعات
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الإنجليزية
Bioinformatics Capstone: Big Data in Biology
In this course, you will learn how to use the BaseSpace cloud platform developed by Illumina (our industry partner) to apply several standard bioinformatics software approaches to real biological data. In particular, in a series of Application Challenges will see how genome assembly can be used to track the source of a food poisoning outbreak, how RNA-Sequencing can help us analyze gene expression data on the tissue level, and compare the pros and cons of whole genome vs.
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Course by
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Self Paced
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13 ساعات
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الإنجليزية
Plant Bioinformatics Capstone
The past 15 years have been exciting ones in plant biology. Hundreds of plant genomes have been sequenced, RNA-seq has enabled transcriptome-wide expression profiling, and a proliferation of "-seq"-based methods has permitted protein-protein and protein-DNA interactions to be determined cheaply and in a high-throughput manner.
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Course by
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Self Paced
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9 ساعات
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الإنجليزية
Documentation and Usability for Cancer Informatics
Introduction: Cancer datasets are plentiful, complicated, and hold information that may be critical for the next research advancements. In order to use these data to their full potential, researchers are dependent on the specialized data tools that are continually being published and developed. Bioinformatics tools can often be unfriendly to their users, who often have little to no background in programming (Bolchini et al. 2008).
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Course by
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Self Paced
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6 ساعات
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الإنجليزية
Comparing Genes, Proteins, and Genomes (Bioinformatics III)
Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins.
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Course by
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Self Paced
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22 ساعات
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الإنجليزية
Genomic Data Science and Clustering (Bioinformatics V)
How do we infer which genes orchestrate various processes in the cell? How did humans migrate out of Africa and spread around the world?
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Course by
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Self Paced
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10 ساعات
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الإنجليزية
Big Data Science with the BD2K-LINCS Data Coordination and Integration Center
The Library of Integrative Network-based Cellular Signatures (LINCS) was an NIH Common Fund program that lasted for 10 years from 2012-2021. The idea behind the LINCS program was to perturb different types of human cells with many different types of perturbations such as drugs and other small molecules, genetic manipulations such as single gene knockdown, knockout, or overexpression, manipulation of the extracellular microenvironment conditions, for example, growing cells on different surfaces, and more.
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Course by
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Self Paced
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9 ساعات
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الإنجليزية
Bioinformatics: Introduction and Methods 生物信息学: 导论与方法
A big welcome to “Bioinformatics: Introduction and Methods” from Peking University! In this MOOC you will become familiar with the concepts and computational methods in the exciting interdisciplinary field of bioinformatics and their applications in biology, the knowledge and skills in bioinformatics you acquired will help you in your future study and research. Course materials are available under the CC BY-NC-SA License.
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Course by
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Self Paced
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الإنجليزية
Finding Mutations in DNA and Proteins (Bioinformatics VI)
In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins. In the first half of the course, we would like to ask how an individual's genome differs from the "reference genome" of the species. Our goal is to take small fragments of DNA from the individual and "map" them to the reference genome.
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Course by
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Self Paced
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24 ساعات
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الإنجليزية
Access Bioinformatics Databases with Biopython
In this 1-hour long project-based course, you will learn how to access, parse, and visualize data from various bioinformatics sequence and structural online databases such as ENTREZ, PDB, KEGG and NCBI using Biopython. You will also interact with various bioinformatics file formats such as FASTA, PDB, GENBANK and XML along with various parsers to read and modify these files using Biopython. Note: This course works best for learners who are based in the North America region. We’re currently working on providing the same experience in other regions.
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Course by
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Self Paced
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2 ساعات
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الإنجليزية
Hacking COVID-19: Metabolic Pathway Analysis Yields SARS-CoV-2 Drug Targets
Pathway Bioinformatics is a subfield of Bioinformatics that is concerned with computationally deriving functional insights from genomic data through analysis of molecular networks. This course will present principles and techniques from Pathway Bioinformatics, and will apply these methodologies to the search for drug targets for SARS-CoV-2. The course will begin by discussing motivations for Pathway Bioinformatics, and by presenting an overview of metabolism and of metabolic pathways. Next it will discuss machine representation of pathway data, and methods for pathway visualization.
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Course by
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Self Paced
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9 ساعات
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الإنجليزية
Plant Bioinformatic Methods
The past 15 years have been exciting ones in plant biology. Hundreds of plant genomes have been sequenced, RNA-seq has enabled transcriptome-wide expression profiling, and a proliferation of "-seq"-based methods has permitted protein-protein and protein-DNA interactions to be determined cheaply and in a high-throughput manner.
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Course by
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Self Paced
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الإنجليزية
Bioinformatics
Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them.
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Course by
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Self Paced
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الإنجليزية
Biology Meets Programming: Bioinformatics for Beginners
Are you interested in learning how to program (in Python) within a scientific setting? This course will cover algorithms for solving various biological problems along with a handful of programming challenges helping you implement these algorithms in Python.
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Course by
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Self Paced
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19 ساعات
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الإنجليزية
Molecular Evolution (Bioinformatics IV)
In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes.
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Course by
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Self Paced
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18 ساعات
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الإنجليزية
Genomics: Decoding the Universal Language of Life
What is a genome? A genome contains all of the information that a cell needs to develop, function, and reproduce itself, and all the information needed for those cells to come together to form a person, plant, or animal. Genomes contain an organism’s complete set of genes, and also the even tinier genetic structures that help regulate when and how those genes are used. The ability to regrow a torn ligament, the clues that might predict the onset of mental illness, the nutritional potential of crops, and even the history of life itself, are all encoded in genomes.
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Course by
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Self Paced
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37 ساعات
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الإنجليزية
Bioinformatic Methods I
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
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Course by
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Self Paced
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20 ساعات
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الإنجليزية
Bioinformatic Methods II
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
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Course by
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Self Paced
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19 ساعات
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الإنجليزية
Finding Hidden Messages in DNA (Bioinformatics I)
Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin?
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Course by
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Self Paced
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16 ساعات
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الإنجليزية