Monthly Subscription Starting at AED 99 + VAT

Case Studies in Personalized Medicine
  • Level Foundation
  • Duration 18 hours
  • Course by Vanderbilt University
  • Offered by

About

Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider.

Modules

WELCOME

    • 1 Videos
    • 1 Readings
Show info about module content

1 Videos

  • A welcome message from Dr. Roden

1 Readings

  • About this course

Module 1: Fundamental Definitions and Concepts

    • 5 Videos
Show info about module content

5 Videos

  • Introduction to Personalized Medicine
  • Genetics Definitions, Part I
  • Genetics Definitions, Part II & Types of Genetic Variants
  • Data Analysis, Part I: What is a Good Study?
  • Data Analysis, Part II: What is a Good Test?

Module 2: Drug Actions and Reactions

    • 5 Videos
Show info about module content

5 Videos

  • Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses
  • Variability in Drug Therapy
  • Drug Metabolism & Transport
  • Genetic Variability in Drug-Handling Molecules
  • **Inside VUMC: The Promise of Personalized Medicine

Unit 1 Discussions & Quiz

    • 5 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Introduction to Personalized Medicine

5 Discussions

  • What kinds of data are helpful?
  • What is a good study?
  • What is a good test?
  • Why might an individual who has a non-sense variant not have a phenotype?
  • What are causes of variability in drug action?

Module 3: Finding Genetic Variants in Families and Populations

    • 4 Videos
Show info about module content

4 Videos

  • Family History and Inheritance Patterns
  • Ancestry: Genetic Variation Across Generations and Geography
  • Finding Disease-Associated Genes: Linkage
  • **Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families

Module 4: Contemporary Techniques and Technologies Used to Study Genetic Variation

    • 3 Videos
Show info about module content

3 Videos

  • Genome-Wide Association
  • Sequencing
  • **Inside VUMC: History of Sequencing Technologies

Unit 2 Discussions & Quiz

    • 4 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Studying Genetic Variation

4 Discussions

  • What are causes of incomplete penetrance?
  • How big should your GWAS sample size be?
  • How big would the odds ratio need to be?
  • Can sequencing inform understanding of common diseases?

Module 5: From Rare Disease to Common Medication - Familial Hypercholesterolemia

    • 3 Videos
Show info about module content

3 Videos

  • From rare to common disease: familial hypercholesterolemia
  • Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia
  • Muscle Pains During Statin Therapy (Myopathy)

Module 6: High Risk Pharmacogenetics

    • 10 Videos
Show info about module content

10 Videos

  • HLA-Mediated Immune Reactions (Skin Rash)
  • Long QT Syndromes, Part 1
  • Long QT Syndromes, Part 2
  • **Inside VUMC: Studying Cardiac Arrhythmias in Cells
  • A Second Heart Attack a Month After a First
  • Headache During Venlafaxine (Antidepressant)
  • Respiratory Arrest After Tonsillectomy
  • A Bleeding Complication 5 Days After Starting Warfarin
  • **Inside VUMC: Genotyping
  • Drug Metabolism and Variable Drug Responses – Four More Examples

Unit 3 Discussions & Quiz

    • 4 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Case Studies, Part I

4 Discussions

  • PCSK9 mutations and familial hypercholesterolemia
  • Simvastatin-related myopathy
  • Which drug-gene interactions warrant testing?
  • Should RCTs be done on every pharmacogenomic association before clinical implementation?

Module 7: From Mechanisms to Treatment

    • 9 Videos
Show info about module content

9 Videos

  • Cystic Fibrosis
  • Marfan Syndrome
  • A Case of Idiopathic Heart Failure
  • Personalizing Care in Neuropsychiatric Disease
  • Personalizing Care in Diabetes
  • Genomics to Subtype Cancer
  • A Family Member With Breast Cancer
  • A Family Member With Colon Cancer
  • **Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions

Unit 4 Discussions & Quiz

    • 4 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Case Studies, Part II

4 Discussions

  • How much should a drug cost?
  • What data are needed in decisions about starting lithium therapy?
  • Would you order a CYP2D6 genotype before starting venlafaxine?
  • When to test for BRCA1 mutations?

Module 8: Where We Are & Where We’re Going

    • 4 Videos
Show info about module content

4 Videos

  • Where We Are Now
  • Where We Are Going
  • **Inside VUMC: Using iPSCs: Drug Discovery and Drug Efficacy
  • **Inside VUMC: Generating iPSCs

Module 9: The Role of the Electronic Medical Record

    • 5 Videos
Show info about module content

5 Videos

  • Electronic Medical Records & The Learning Healthcare System (Discovery)
  • Using Electronic Records to Personalize Care (Delivery)
  • **Inside VUMC: Using the EMR to Ascertain Patients for Genetic Studies
  • **Inside VUMC: Biobanking & DNA Extraction at BioVU
  • **Inside VUMC: Personalized Medicine is a Team Sport

Unit 5 Discussions & Quiz

    • 3 Discussion
    • 1 Assignment
Show info about module content

1 Assignment

  • Personalized Medicine in a System of Care

3 Discussions

  • What limits our use of genomic sequencing data in practice?
  • What are possible drawbacks to widespread use of EMRs?
  • What are the barriers to widespread implementation of genomic medicine?

CHOOSE ONLY ONE:

    • 2 PeerReview
Show info about module content

2 Peer Review

  • For Healthcare Professionals
  • For a General Audience (not Healthcare Professionals)

Auto Summary

"Case Studies in Personalized Medicine" is a comprehensive course designed to explore the transformative potential of biomedicine in drug development, treatment personalization, and disease prevention. This course delves into the current advancements and future possibilities within the realm of personalized medicine, offering a deep dive into genetics and the variability in drug responses. Led by Coursera, the course is tailored primarily for experienced physicians (with over five years of practice), though it is also suitable for other healthcare providers, medical and health sciences students, and even interested members of the public. Through a series of insightful case studies, learners will grasp how genetic information is utilized to enhance diagnostic accuracy and tailor treatments for both rare and common diseases. It also addresses the ethical and operational challenges of implementing large-scale genomic sequencing in clinical settings. Upon completion, participants will gain a robust understanding of the genetic factors influencing disease susceptibility, the criteria for selecting drug therapies based on genetic profiles, and the complexities surrounding the functional impacts of numerous genetic variants identified through modern sequencing techniques. The course spans a substantial duration of 1080 minutes and offers a foundational level of instruction. Aspiring learners can subscribe to the Starter plan to gain access to this enriching educational experience, beginning from its launch on January 15, 2016. This course is an invaluable resource for those looking to stay at the forefront of personalized medicine and its practical applications in healthcare.

Dan Roden, M.D.
Instructor

Dan Roden, M.D.