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Evidence-based Toxicology
  • Level Foundation
  • Duration 20 hours
  • Course by Johns Hopkins University
  • Offered by

About

Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology. The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment. Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

Modules

Introduction

    • 2 Videos
    • 2 Readings
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2 Videos

  • Welcome
  • Introduction to the Course

2 Readings

  • Letter to Learners
  • Course Learning Objectives

Shortcomings of current approaches in toxicology

    • 7 Videos
    • 1 Readings
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7 Videos

  • Introduction
  • Shortcoming No. 1: Narrative Reviews
  • Shortcoming No. 2: Bias in Reviews
  • Shortcoming No. 3: Evidence Writing
  • Shortcoming No. 4: External Validity
  • Shortcoming No. 5: Assessing New Methods
  • Shortcoming No. 6: Inadequate Reporting

1 Readings

  • Supporting reading

Check your knowledge

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice Quiz 1

1 Discussions

  • Rank the shortcomings

Welcome

    • 1 Videos
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1 Videos

  • Welcome to Module 2

Start of Evidence-Based Toxicology

    • 4 Videos
    • 1 Readings
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4 Videos

  • Personal First Exposures to Evidence-Based Medicine
  • The Start of EBT
  • The First Conference 2007 to the Start of the EBT Collaboration 2011
  • The Evidence-Based Toxicology Collaboration (EBTC)

1 Readings

  • Supporting reading

Causation and Evidence-Based Toxicology

    • 6 Videos
    • 1 Readings
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6 Videos

  • Introduction Causation vs. Correlation
  • The Hill Principles of Epidemiology and their Relation to Toxicology
  • The Problem of Causation in Toxicology
  • Biomarker Concept in Mechanistic Toxicology
  • Mechanistic Validation
  • The Future of Causation in Complex Systems

1 Readings

  • Supporting reading

Review

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice Quiz 2

1 Discussions

  • Importance of EBT

Welcome

    • 1 Videos
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1 Videos

  • Welcome to Module 3

Systematic Reviews – principles and examples

    • 3 Videos
    • 1 Readings
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3 Videos

  • Systematic Reviews: Definition and Principles
  • Systematic Reviews - Protocol Development
  • Systematic Reviews - Protocol Development (Part 2)

1 Readings

  • Supporting reading

Introduction to Meta-analysis

    • 4 Videos
    • 1 Readings
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4 Videos

  • History
  • Meta-analysis Guidelines
  • Meta-analysis Protocol, Part 1
  • Meta-analysis Protocol, Part 2

1 Readings

  • Supporting reading

Module 3 Review

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice Quiz 3

1 Discussions

  • Systematic Review and Meta-analysis

Mid-course exam

    • 1 Assignment
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1 Assignment

  • Mid-course exam

Welcome

    • 1 Videos
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1 Videos

  • Welcome to Module 4

Risk of Bias in Evidence-Based Toxicology

    • 5 Videos
    • 1 Readings
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5 Videos

  • Introduction to Risk of Bias Concept in Critical Appraisal of Studies
  • Examples for Risk of Bias Tools 1: Cochrane Collboration
  • Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool
  • Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT
  • Quality Assessment in Evidence-Based Toxicology

1 Readings

  • Supporting reading

Evidence-Based Toxicology: Application to Test Methods Comparison

    • 2 Videos
    • 1 Readings
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2 Videos

  • Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)
  • Zebrafish Systematic Review

1 Readings

  • Supporting reading

Module 4 Review

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice Quiz 4

1 Discussions

  • Risk of Bias is important to consider

Welcome

    • 1 Videos
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1 Videos

  • Welcome to Module 5

Quality Assurance and Good Practices

    • 4 Videos
    • 1 Readings
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4 Videos

  • The Concepts of Quality Assurance (QA) and Good Practice (GP)
  • Good Practice
  • Quality Assurance
  • Importance of GP and QA in EBT

1 Readings

  • Supporting reading

Validation

    • 5 Videos
    • 1 Readings
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5 Videos

  • The Evolution of Validation of Alternative Methods
  • The Traditional Validation Process
  • Example of a Validation Study: Skin Irritation
  • Developments in the Validation Area
  • Validation and Tox-21c/EBT

1 Readings

  • Supporting reading

Module 5 Review

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice Quiz 5

1 Discussions

  • Changes in the validation process

Welcome

    • 1 Videos
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1 Videos

  • Welcome to Module 6

Biometrical Tools in Evidence-Based Toxicology

    • 4 Videos
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4 Videos

  • Why We Need Biometry/Statistics in Evidence-Based Toxicology
  • Statistics and Bioinformatics Applied in Evidence-Based Approaches I
  • Statistics and Bioinformatics Applied in Evidence-Based Approaches II
  • Risk and Bias and Its Impact on Evidence-Based Approaches

Future Perspectives of Evidence-Based Toxicology

    • 3 Videos
    • 1 Readings
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3 Videos

  • Evidence-Based Is a More Rigorous Scientific Approach to Anything
  • The Reproducibility Crisis in Science
  • Where Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?

1 Readings

  • Supporting reading

Module 6 Review

    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Practice quiz 6

1 Discussions

  • Reproducibility crisis

Final exam

    • 1 Assignment
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1 Assignment

  • Final exam

Assignment

    • 1 Readings
    • 1 Plugin
    • 1 Assignment
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1 Assignment

  • Systematic Review Assignment Results

1 Readings

  • Systematic Review Assignment Instructions

Auto Summary

Discover the "Evidence-based Toxicology" course, led by experts from Johns Hopkins Bloomberg School of Public Health. This foundational course explores the adaptation of evidence-based approaches in toxicology, mirroring advancements in medicine. Over approximately 1200 minutes, you'll learn about emerging regulatory tools and systematic reviews. Available via Coursera with Starter and Professional subscription options, this course is ideal for those in Science and Engineering looking to enhance their understanding of modern toxicology practices.

Thomas Hartung
Instructors

Thomas Hartung

Lena Smirnova
Instructors

Lena Smirnova