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Medical Neuroscience
  • Level Expert
  • Duration 71 hours
  • Course by Duke University
  • Offered by

About

Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience. This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam: - Unit 1 Neuroanatomy (weeks 1-2). This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord. - Unit 2 Neural signaling (weeks 3-4). This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity. - Unit 3 Sensory systems (weeks 5-7). Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses. - Unit 4 Motor systems (weeks 8-9). In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement. - Unit 5 Brain Development (week 10). Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life; we will also consider how the brain changes across the lifespan. - Unit 6 Cognition (weeks 11-12). The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future; we will also consider brain systems for maintaining homeostasis and regulating brain state.

Modules

Getting to Know Professor White and Medical Neuroscience

    • 5 Videos
    • 2 Readings
    • 1 Assignment
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1 Assignment

  • Preliminary Quiz: Are you ready for Medical Neuroscience?

5 Videos

  • Professor White's Career in Neuroscience
  • The Scope of Medical Neuroscience
  • Learning resources for Medical Neuroscience
  • Your Part!
  • "Neur-run" with Professor White

2 Readings

  • Learning Objectives
  • Your Mentor Team

Getting to Know the Human Brain

    • 4 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Cells of the CNS and Basic Orientation

4 Videos

  • Professor White's Favorite Places in the Human Brain
  • Functional Microanatomy of Neurons
  • Non-Neural Cells of the CNS
  • Basic Orientation in the Human CNS

1 Readings

  • Introduction, Learning Objectives and Recommended Reading

Cerebral Cortex, Brainstem, and Blood Supply

    • 7 Videos
    • 1 Readings
    • 2 Discussion
    • 1 Assignment
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1 Assignment

  • Cerebral Cortex, Brainstem, and Blood Supply

2 Discussions

  • Let's Discuss: Is Bigger Better?
  • Visualize Your Knowledge: Surface Features of the Cerebral Hemispheres

7 Videos

  • Lateral Surface of the Brain
  • Medial Surface of the Brain
  • Finding the Central Sulcus
  • Ventral Surface of the Brain
  • Building a Digital Brain (Fingers to Gyri)
  • Surface Anatomy of the Brainstem
  • Blood Supply to the Brain

1 Readings

  • Learning Objectives / Recommended Readings

Cranial and Spinal Nerves

    • 5 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Cranial and Spinal Nerves

1 Discussions

  • Let's #GetNeuro: Doing Medical Neuroscience

5 Videos

  • Overview of the Cranial Nerves
  • Overview of the Spinal Nerves
  • Localizing the Cranial Nerves
  • Cranial Nerve Function, part 1
  • Cranial Nerve Function, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Brainstem and Spinal Cord

    • 8 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Brainstem and Spinal Cord

8 Videos

  • Internal Anatomy of the Brainstem
  • Cranial Nerve Nuclei, part 1
  • Cranial Nerve Nuclei, part 2
  • Cranial Nerve Nuclei, part 3
  • Cranial Nerve Nuclei, part 4
  • Internal Anatomy of the Spinal Cord - Gray and White Matter
  • Internal Anatomy of the Spinal Cord -Longitudinal Organization
  • Internal Anatomy of the Spinal Cord In Cross Sections

1 Readings

  • Learning Objectives / Recommended Readings

Forebrain

    • 4 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Forebrain

1 Discussions

  • Let's Discuss: What Makes Us Human?

4 Videos

  • Ventricles
  • Overview of the Internal Capsule and Deep Gray Matter
  • Localizing the Internal Capsule and Deep Gray Matter In Brain Slabs
  • Localizing the Internal Capsule and Deep Gray Matter In Sylvius Atlases

1 Readings

  • Learning Objectives / Recommended Readings

Generating and Propagating Electrical Signals

    • 9 Videos
    • 1 Readings
    • 3 Discussion
    • 1 Assignment
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1 Assignment

  • Generating and Propagating Electrical Signals

3 Discussions

  • Let's #GetNeuro: Neuroscience in Nature
  • Let's Discuss: A Moment in Time
  • Clinical Case Studies: An Older Woman with a Transient Ischemic Attack

9 Videos

  • Overview of Neuronal Signaling
  • Ionic Basis of the Resting Membrane Potential, part 1
  • Ionic Basis of the Resting Membrane Potential, part 2
  • Ionic Basis of the Action Potential, part 1
  • Ionic Basis of the Action Potential, part 2
  • Ionic Basis of the Action Potential, part 3
  • Molecular Mechanisms of Action Potential Generation, part 1
  • Molecular Mechanisms of Action Potential Generation, part 2
  • Propagation of Action Potentials

1 Readings

  • Learning Objectives / Recommended Readings

Synaptic Transmission

    • 8 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Synaptic Transmission

8 Videos

  • Synaptic Transmission, part 1
  • Synaptic Transmission, part 2
  • Neurotransmitters, part 1
  • Neurotransmitters, part 2
  • Ionotropic Neurotransmitters Receptors, part 1
  • Ionotropic Neurotransmitters Receptors, part 2
  • Metabotropic Neurotransmitters Receptors and Postsynaptic Mechanisms
  • Synaptic Integration

1 Readings

  • Learning Objectives / Recommended Readings

Synaptic Plasticity

    • 5 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Synaptic Plasticity

1 Discussions

  • Lets' Discuss: Use it or Lose It?

5 Videos

  • Long-Term Potentiation and Depression, part 1
  • Long-Term Potentiation and Depression, part 2
  • Long-Term Potentiation and Depression, part 3
  • Spike-Timing Dependent synaptic Plasticity
  • Hebb's Postulate

1 Readings

  • Learning Objectives / Recommended Readings

Organizing Prinicples

    • 5 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Organizing Principles

1 Discussions

  • Lets' Discuss: How Many Senses?

5 Videos

  • The Thalamus
  • Overview and Origins of Cortical Circuits, part 1
  • Overview and Origins of Cortical Circuits, part 2
  • General Principles of Sensory Systems, part 1
  • General Principles of Sensory Systems, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Somatic Sensation

    • 11 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Somatic Sensation

1 Discussions

  • Clinical Case Studies: Frequent Finger Burns

11 Videos

  • Mechanosensation, part 1
  • Mechanosensation, part 2
  • Mechanosensation, part 3
  • Mechanosensory Pathways, part 1
  • Mechanosensory Pathways, part 2
  • Mechanosensory Pathways, part 3
  • Pain Systems, part 1
  • Pain Systems, part 2
  • Pain Systems, part 3
  • Pain and Temperature Pathways, part 1
  • Pain and Temperature Pathways, part 2

1 Readings

  • Learning Objectives / Recommended Readings

The Eye

    • 5 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • The Eye

5 Videos

  • Basic Structure of the Eye and Retina
  • Photoreceptors and Phototransduction, part 1
  • Photoreceptors and Phototransduction, part 2
  • Ganglion Cell Receptive fields, part 1
  • Ganglion Cell Receptive fields, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Central Visual Processing

    • 7 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Central Visual Processing

7 Videos

  • Central Visual Processing, part 1
  • Central Visual Processing, part 2
  • Central Visual Processing, part 3
  • Central Visual Pathways, part 1
  • Central Visual Pathways, part 2
  • Visual Field Deficits
  • Pupillary Light Reflex

1 Readings

  • Learning Objectives / Recommended Readings

Audition

    • 6 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Audition

6 Videos

  • Peripheral Auditory Mechanisms, part 1
  • Peripheral Auditory Mechanisms, part 2
  • Peripheral Auditory Mechanisms, part 3
  • Central Auditory Processing, part 1
  • Central Auditory Processing, part 2
  • Central Auditory Processing, part 3

1 Readings

  • Learning Objectives / Recommended Readings

Vestibular Sensation

    • 7 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Vestibular Sensation

7 Videos

  • Peripheral Vestibular Mechanisms, part 1
  • Peripheral Vestibular Mechanisms, part 2
  • Peripheral Vestibular Mechanisms, part 3
  • Central Vestibular Processing, part1
  • Central Vestibular Processing, part 2
  • Central Vestibular Processing, part 3
  • Central Vestibular Processing, part 4

1 Readings

  • Learning Objectives / Recommended Readings

Chemical Senses

    • 9 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Chemical Senses

1 Discussions

  • Lets' Discuss: Synesthesia

9 Videos

  • Overview of the Chemical Senses
  • Olfaction, part 1
  • Olfaction, part 2
  • Olfaction, part 3
  • Olfaction, part 4
  • Gustation, part1
  • Gustation, part 2
  • Gustation, part 3
  • Trigeminal Chemoreception

1 Readings

  • Learning Objectives / Recommended Readings

Lower Motor Neuronal Control of Movement

    • 8 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Lower Motor Neuronal Control of Movement

1 Discussions

  • Lets' Discuss: Muscle Memory

8 Videos

  • Overview of the Motor System
  • Overview of Motor Units
  • Muscle Spindles and Myotatic Reflexes, part 1
  • Muscle Spindles and Myotatic Reflexes, part 2
  • Golgi Tendon Organs
  • Spindles Versus GTOs, and Withdrawal Reflexes
  • Central Pattern Generation
  • Lower Motor Syndrome

1 Readings

  • Learning Objectives / Recommended Readings

Upper Motor Neuronal Control of Movement

    • 10 Videos
    • 1 Readings
    • 3 Discussion
    • 1 Assignment
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1 Assignment

  • Upper Motor Neuronal Control of Movement

3 Discussions

  • Clinical Case Studies: NeuroLogical Case No. 1 (University of Utah) - The Upset Office Manager
  • Lets' Discuss: Decussations
  • Clinical Case Studies: Right Arm and Leg Paralysis, with Tongue Weakness

10 Videos

  • Primary Motor Cortex, part 1
  • Primary Motor Cortex, part 2
  • Primary Motor Cortex, part 3
  • Premotor Cortex
  • Brainstem Upper Motor Neurons
  • Emotional Motor System
  • Control of Facial Expressions
  • Upper Motor Neuron Syndrome
  • Corticospinal and Corticobulbar Pathways, part 1
  • Corticospinal and Corticobulbar Pathways, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Eye Movements

    • 6 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Eye Movements

6 Videos

  • Muscles and Nerves
  • Overview of Eye Movements
  • Conjugate Eye Movements
  • Disconjugate Eye Movements and Eye Movement Physiology
  • Neural Control of Saccades, part 1
  • Neural Control of Saccades, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Modulation of Movement by the Basal Ganglia

    • 5 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Modulation of Movement by the Basal Ganglia

5 Videos

  • Circuitry of the Basal Ganglia, part 1
  • Circuitry of the Basal Ganglia, part 2
  • Circuitry of the Basal Ganglia, part 3
  • Function of Basal Ganglia Circuitry
  • Basal Ganglia Function In Normal and Abnormal Movement

1 Readings

  • Learning Objectives / Recommended Readings

Modulation of Movement by the Cerebellum

    • 6 Videos
    • 1 Readings
    • 2 Discussion
    • 1 Assignment
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1 Assignment

  • Modulation of Movement by the Cerebellum

2 Discussions

  • Lets' Discuss: Is Bigger Better?
  • Clinical Case Studies: NeuroLogical Case No. 3 (University of Utah) - Woman with Unsteadiness

6 Videos

  • Overview of the Cerebellum, part 1
  • Overview of the Cerebellum, part 2
  • Cerebellar Circuits, part 1
  • Cerebellar Circuits, part 2
  • Cerebellar Circuits, part 3
  • Cerebellar Function In Normal and Abnormal Movement

1 Readings

  • Learning Objectives / Recommended Readings

Visceral Motor System

    • 8 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Visceral Motor System

1 Discussions

  • Clinical Case Studies: Awoke to Ptosis, Hoarseness, and Difficulty Swallowing

8 Videos

  • Functional and Anatomical Divisions of the Visceral Motor System, part 1
  • Functional and Anatomical Divisions of the Visceral Motor System, part 2
  • Functional and Anatomical Divisions of the Visceral Motor System, part 3
  • Central Integration of Visceral Sensory and Motor Signals, part 1
  • Central Integration of Visceral Sensory and Motor Signals, part 2
  • Hypothalamus, part 1
  • Hypothalamus, part 2
  • Micturition

1 Readings

  • Learning Objectives / Recommended Readings

Early Brain Development

    • 12 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Early Brain Development

12 Videos

  • Embryological Subdivisions of the Human CNS
  • Major Forces In Early Brain Development
  • Neurulation
  • Formation of the Early CNS
  • Inductive Signaling In CNS Formation
  • Proliferation and Migration, part 1
  • Proliferation and Migration, part 2
  • Growth Cones
  • Molecular Signals for Axon Guidance, part 1
  • Molecular Signals for Axon Guidance, part 2
  • Neurotrophins
  • Neurotrophin Receptors and Synapse Formation

1 Readings

  • Learning Objectives / Recommended Readings

Developmental Plasticity of Neural Circuits In Early Life

    • 6 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Developmental Plasticity of Neural Circuits In Early Life

6 Videos

  • Lessons from Studies of Ocular Dominance Columns, part 1
  • Lessons from Studies of Ocular Dominance Columns, part 2
  • Lessons from Studies of Orientation and Direction Preference, part 1
  • Lessons from Studies of Orientation and Direction Preference, part 2
  • Lessons from Studies of Orientation and Direction Preference, part 3
  • Neurotrophins In Developmental Plasticity

1 Readings

  • Learning Objectives / Recommended Readings

Development, Repair and Regeneration Across the Lifespan

    • 5 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Development, Repair and Regeneration Across the Lifespan

1 Discussions

  • Clinical Case Studies: NeuroLogical Case No. 2 (University of Utah): Girl with Sudden Weakness

5 Videos

  • Brain Development Across the Lifespan, part 1
  • Brain Development Across the Lifespan, part 2
  • Functional Plasticity In Cortical Maps
  • Repair and Regeneration, part 1
  • Repair and Regeneration, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Associational Cortex

    • 11 Videos
    • 1 Readings
    • 2 Discussion
    • 1 Assignment
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1 Assignment

  • Associational Cortex

2 Discussions

  • Let's #GetNeuro: In Poetic Forms
  • Lets' Discuss: Grounded Cognition

11 Videos

  • Overview of Cognition
  • Overview of the Associational Cortex
  • Parietal Associational Cortex, part 1
  • Parietal Associational Cortex, part 2
  • Temporal associational Cortex: Visual Recognition
  • Temporal Associational Cortex: Memory, part 1
  • Temporal Associational Cortex: Memory, part 2
  • Temporal Associational Cortex: Language, part 1
  • Temporal Associational Cortex: Language, part 2
  • Frontal Associational Cortex: Working Memory
  • Frontal Associational cortex: Exeutive Function

1 Readings

  • Learning Objectives / Recommended Reading

Sleep and Wakefulness

    • 6 Videos
    • 1 Readings
    • 1 Assignment
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1 Assignment

  • Sleep and Wakefulness

6 Videos

  • Overview of Sleep and Wakefulness
  • Circadian Rhythms
  • Brain Waves and Sleep Stages
  • Neural Circuits That Govern Sleep and Wakefulness, part 1
  • Neural Circuits That Govern Sleep and Wakefulness, part 2
  • Sleep Disorders

1 Readings

  • Learning Objectives / Recommended Readings

Limbic Forebrain, Emotion, and Addiction

    • 7 Videos
    • 1 Readings
    • 1 Discussion
    • 1 Assignment
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1 Assignment

  • Limbic Forebrain, Emotion, and Addiction

1 Discussions

  • Lets' Discuss: "Higher" Brain Function

7 Videos

  • Amygdala and Hippocampus In the Human Brain
  • Neurobiology of Emotion, part 1
  • Neurobiology of Emotion, part 2
  • Neurobiology of Emotion, part 3
  • Neurobiology of Emotion, part 4
  • Reward and Addiction, part 1
  • Reward and Addiction, part 2

1 Readings

  • Learning Objectives / Recommended Readings

Preparing for the Comprehensive Final Exam

    • 1 Videos
    • 1 Readings
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1 Videos

  • Preparing for the Comprehensive Final Exam

1 Readings

  • Preparation Notes

Final Exam Preparation

    • 1 Assignment
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1 Assignment

  • Example Clinical Case Quiz (UNGRADED, 11 questions)

Comprehensive Final Exam (4 sections)

    • 4 Assignment
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4 Assignment

  • Comprehensive Final Exam, part 1 (2 cases, 13 questions)
  • Comprehensive Final Exam, part 2 (2 cases, 7 questions)
  • Comprehensive Final Exam, part 3 (2 cases, 11 questions)
  • Comprehensive Final Exam, part 4 (2 cases, 12 questions)

Closing Remarks

    • 1 Videos
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1 Videos

  • Closing Remarks from Dr. White (05:44)

Auto Summary

Embark on an in-depth journey into the world of Medical Neuroscience with this expert-level online course designed for those passionate about understanding the human central nervous system. Offered by Coursera and led by the esteemed Duke University School of Medicine, this course delves into the intricacies of neurophysiology and neuroanatomy, providing a robust neurobiological framework to comprehend human behavior. Over 12 weeks, you will explore six meticulously structured units that cover vital aspects of the nervous system: - Begin with **Neuroanatomy**, understanding the brain's surface anatomy, internal structure, and the sensory and motor systems. - Move on to **Neural Signaling**, where you'll learn about neuronal excitability, synaptic transmission, and neural plasticity. - Delve into the **Sensory Systems**, discovering how somatic senses, proprioception, vision, audition, and balance contribute to our perception of the world. - Study the **Motor Systems** to understand the brain and spinal mechanisms governing movement. - Explore the **Brain Development** unit, focusing on the neurobiological mechanisms from embryonic development to postnatal life and how the brain evolves over a lifetime. - Conclude with **Cognition**, examining cortical networks, perception, memory, emotion, and the brain's role in behavior and homeostasis. This course is designed to match the rigor of a first-year medical school curriculum, making it ideal for advanced learners and professionals seeking a comprehensive understanding of the central nervous system. While it includes all core concepts of neurophysiology and clinical neuroanatomy, it does not cover some aspects like biological psychiatry or hands-on brain dissection. With a total duration of approximately 4260 minutes, this subscription-based course offers a challenging yet rewarding learning experience for those ready to elevate their knowledge to an expert level. Join now and lay a solid foundation for diagnosing and understanding central nervous system impairments related to sensation, action, and cognition.

Leonard E. White, Ph.D.
Instructor

Leonard E. White, Ph.D.