Toxicology 21: Scientific Applications
This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
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- Level Professional
- Duration 96 hours
- Course by Johns Hopkins University
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Offered by
About
This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report "Toxicity Testing in the 21st Century: A Vision and a Strategy." We present the latest developments in the field of toxicology"the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.Modules
Welcome to the Course
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2
Videos
2
Videos
- Welcome to Module 1
- Course Introduction
Drivers for Change
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4
Videos
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2
Readings
4
Videos
- Introduction
- Center for Alternatives to Animal Testing
- Toxicology of the Fifteenth to Twentieth Centuries
- Toxicology for the Twenty-First Century
2
Readings
- useful links
- supporting reading material
The National Research Council (NRC) Report - Toxicity Testing in the 21st Century: A Vision and a Strategy
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4
Videos
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1
Readings
4
Videos
- Historical Perspective
- The First Report: Toxicity Testing for Assessment of Environmental Agents
- The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components
- The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation
1
Readings
- Supporting reading material
Check your knowledge
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1
Discussion
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1
Assignment
1
Assignment
- Module 1 Quiz
1
Discussions
- Drivers of change
US EPA Endocrine Disruptor Screening Program (EDSP)
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5
Videos
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2
Readings
5
Videos
- Welcome to Module 2
- Adverse Outcome Pathways (AOPs)
- Exposure-Based Chemical Prioritization
- ER Bioactivity Model
- US EPA Endocrine Disruptor Screening Program (EDSP)
2
Readings
- Supporting Reading Material
- Useful links
Modeling of Hazard and Organ Manifestation
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5
Videos
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2
Readings
5
Videos
- Modeling of Hazard and Organ Manifestation
- Building a Signature for Vascular Disruption
- Testing the Vascular Disruption Signature
- Virtual Tissue Model: Vascular Development
- Functional Vascular Development Assays
2
Readings
- Supporting Reading Material
- Useful links
Check your knowledge
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2
Discussion
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1
Assignment
1
Assignment
- Module 2 Quiz
2
Discussions
- Tox21 vs. ToxCast
- AOP
Assignment 1: CompTox to prioritize chemicals
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1
PeerReview
1
Peer Review
- Chemical report and endocrine disrpution potency prediction
The Human Toxome Project
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6
Videos
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1
Readings
6
Videos
- Welcome to Module 3
- Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology
- The Concept of the Human Toxome Project
- Concept and Tool Devlopment
- Progress
- Conclusions and Prospectives
1
Readings
- Supporting reading materials
Pathways of Toxicity from Omics Data
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4
Videos
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1
Readings
4
Videos
- Introduction: What Is a Pathway of Toxicity, and Why Do We Need Them?
- Omics Technologies and High-Throughput Data
- Interpreting Omics Data
- Using Network Approaches to Understand Toxicity Mechanisms
1
Readings
- Supporting reading material
Check your knowledge
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1
Discussion
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1
Assignment
1
Assignment
- Module 3 Quiz
1
Discussions
- Challenges in implementing omics technologies for high throughput assays
The Adverse Outcome Pathway Framework: The Foundation for Predictive Toxicology
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5
Videos
5
Videos
- The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive Tools
- The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology
- Introduction to the OECD AOP Framework
- Building, Evaluating, and Using AOPs in Safety Decisions
- Online Tools Available to Everyone, Including an Online AOP Course
Read-Across
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6
Videos
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1
Readings
6
Videos
- Welcome to Module 4
- Introduction to Read-Across
- Good Read-Across Practice
- Supporting Read-Across with Biological Data
- Creating a Database of Toxicity
- Creating an Automated Tool for Read-Across
1
Readings
- Supporting reading material
Microphysiological Systems (Organ-on-Chip, Organoids, Organotypic Cultures) in Toxicology: Next Generation of Cell Cultures
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7
Videos
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2
Readings
7
Videos
- Cell Sources for In Vitro Models
- Monolayer Cultures
- Advanced Cell Cultures: Microphysiological Systems (MPS)
- 3D Cultures
- Microfluidics
- Organ-on-Chip, Body-on-Chip
- Good Cell Culture Practice
2
Readings
- Supporting reading material
- Useful links
Check your knowledge
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1
Discussion
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1
Assignment
1
Assignment
- Module 4 Quiz
1
Discussions
- Read-across
Mid-term exam
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1
Assignment
1
Assignment
- Mid-term exam
Micro-RNA and epigenetics
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6
Videos
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1
Readings
6
Videos
- Welcome to Module 5
- MicroRNA and Epigenetics
- Epigenetics and Environment
- MicroRNA: Biogenesis and Functions
- Role of MicroRNA in Development
- MicroRNA in Toxicology
1
Readings
- Supporting reading material
Check your knowledge
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1
Discussion
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1
Assignment
1
Assignment
- Module 5 Quiz
1
Discussions
- MicroRNAs potential to be biomarkers for diseases and toxicity
Biokinetic Modeling of Toxicokinetics
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5
Videos
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1
Readings
5
Videos
- Welcome to Module
- Physiologically Based Biokinetic Modeling
- Application of QIVIVE to in Vitro Testing
- Challenges for Conducting QIVIVE
- Quantitative in Vitro to in Vivo Extrapolation
1
Readings
- Supporting reading material
Biometry and Data-mining
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3
Videos
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2
Readings
3
Videos
- Definition of Biometry/Biostatistics and Revisiting Some Statistical Basics
- Types of Tox21 Data and Data Mining of External Data Sources
- Bioinformatics Tools for the Interpretation of Tox21 Data
2
Readings
- Supporting reading material
- Useful links
Check your knowledge
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1
Assignment
1
Assignment
- Module 6 Quiz
Peer Assessment 2 (to be moved)
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1
PeerReview
1
Peer Review
- Peer Assessment 2: Summarizing Your Knowledge on Tools and Applications in Toxicology in the 21st Century
Integrated Testing Strategies
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6
Videos
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1
Readings
6
Videos
- Welcome to Module 7
- Why Integrated Testing Strategies?
- What is an Integrated Testing Strategy?
- How to Compose Integrated Testing Strategies
- Strategies for Integrated Testing Strategies
- Quality Assurance of integrated Testing Strategies
1
Readings
- Supporting reading material
Beyond Chemicals
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5
Videos
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1
Readings
5
Videos
- Legal Background
- Economic Background
- Tox-21c for Drug Safety
- Green Toxicology as Non-regulatory Tox-21c Approaches
- Conclusions and Prospects
1
Readings
- Supporting reading material
Check your knowledge
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1
Assignment
1
Assignment
- Module 7 Quiz
Final Exam
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1
Assignment
1
Assignment
- Final Exam
Auto Summary
"Toxicology 21: Scientific Applications" is a professional course in Science & Engineering, offered by Coursera. Focused on modernizing regulatory toxicology, it delves into high-content, high-throughput testing strategies, moving away from animal testing. The course showcases active programs from EPA, NIH, and global scientific communities, inspired by the NRC report. Ideal for professionals, it spans 5760 minutes and is available with a Starter subscription.
Lena Smirnova
Thomas Hartung