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دوراتنا
Using Shiny to Plot Differential Gene Expression
In this project-based course, you will create a Shiny app to plot gene expression data (Real-Time PCR) from a published manuscript. You will build the Shiny app from scratch and handle every component of Shiny. The project covers data processing and collecting feedback from the user to build and finetune the output.
In this course, we will be concerned with the optimal use of inputs and outputs. Instead of building a lot of inputs and outputs, we will use a limited number of components and recycle some even seven times for different purposes.
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Course by
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Self Paced
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2 ساعات
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الإنجليزية
Basic Principles of Cell Signaling
The coordination of life in multicellular organisms is precisely controlled by cells via various internal and external signals. Cells depend on different types of signals to regulate their growth, division, metabolism as well as death. Signals are growth factors or hormones produced and secreted by other cells. Some signals such as nutrients are in the form of molecules from the environment. Signaling molecules are sensed by direct binding to specific receptor molecules.
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Course by
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Self Paced
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9 ساعات
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الإنجليزية
Big Data Science with the BD2K-LINCS Data Coordination and Integration Center
The Library of Integrative Network-based Cellular Signatures (LINCS) was an NIH Common Fund program that lasted for 10 years from 2012-2021. The idea behind the LINCS program was to perturb different types of human cells with many different types of perturbations such as drugs and other small molecules, genetic manipulations such as single gene knockdown, knockout, or overexpression, manipulation of the extracellular microenvironment conditions, for example, growing cells on different surfaces, and more.
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Course by
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Self Paced
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9 ساعات
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الإنجليزية
Genomic Data Science and Clustering (Bioinformatics V)
How do we infer which genes orchestrate various processes in the cell? How did humans migrate out of Africa and spread around the world?
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Course by
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Self Paced
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10 ساعات
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الإنجليزية
Classical papers in molecular genetics
You have all heard about the DNA double helix and genes. Many of you know that mutations occur randomly, that the DNA sequence is read by successive groups of three bases (the codons), that many genes encode enzymes, and that gene expression can be regulated. These concepts were proposed on the basis of astute genetic experiments, as well as often on biochemical results.
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Course by
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Self Paced
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28 ساعات
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الإنجليزية
Bioinformatics Capstone: Big Data in Biology
In this course, you will learn how to use the BaseSpace cloud platform developed by Illumina (our industry partner) to apply several standard bioinformatics software approaches to real biological data. In particular, in a series of Application Challenges will see how genome assembly can be used to track the source of a food poisoning outbreak, how RNA-Sequencing can help us analyze gene expression data on the tissue level, and compare the pros and cons of whole genome vs.
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Course by
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Self Paced
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13 ساعات
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الإنجليزية
Introduction to Systems Biology
This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability.
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Course by
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Self Paced
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19 ساعات
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الإنجليزية
Epigenetic Control of Gene Expression
While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability.
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Course by
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Self Paced
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17 ساعات
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الإنجليزية
Bioinformatic Methods II
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
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Course by
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Self Paced
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19 ساعات
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الإنجليزية
Bioinformatic Methods I
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
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Course by
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Self Paced
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20 ساعات
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الإنجليزية
Machine Learning: Regression
Case Study - Predicting Housing Prices In our first case study, predicting house prices, you will create models that predict a continuous value (price) from input features (square footage, number of bedrooms and bathrooms,...). This is just one of the many places where regression can be applied.
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Course by
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Self Paced
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22 ساعات
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الإنجليزية